1s9l

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[[Image:1s9l.png|left|200px]]
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==NMR Solution Structure of a Parallel LNA Quadruplex==
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<StructureSection load='1s9l' size='340' side='right' caption='[[1s9l]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1s9l]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S9L FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LCG:[(1R,3R,4R,7S)-7-HYDROXY-3-(GUANIN-9-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>LCG</scene>, <scene name='pdbligand=TLN:[(1R,3R,4R,7S)-7-HYDROXY-3-(THYMIN-1-YL)-2,5-DIOXABICYCLO[2.2.1]HEPT-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>TLN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s9l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s9l RCSB], [http://www.ebi.ac.uk/pdbsum/1s9l PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of a locked nucleic acid (LNA) quadruplex, formed by the oligomer d(TGGGT), containing only conformationally restricted LNA residues is reported. NMR and CD spectroscopy, as well as molecular dynamics and mechanic calculations, has been used to characterize the complex. The molecule adopts a parallel stranded conformation with a 4-fold rotational symmetry, showing a right-handed helicity and the guanine residues in an almost planar conformation with three well-defined G-tetrads. The thermal stability of Q-LNA has been found to be comparable with that of [r(UGGGU)]4, while a T(m) increment of 20 degrees C with respect to the corresponding DNA quadruplex structure [d(TGGGT)]4 has been observed. The structural features of the LNA quadruplex reported here may open new perspectives for the biological application of LNAs as novel versatile tools to design aptamer or catalyst oligonucleotides.
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{{STRUCTURE_1s9l| PDB=1s9l | SCENE= }}
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NMR solution structure of a parallel LNA quadruplex.,Randazzo A, Esposito V, Ohlenschlager O, Ramachandran R, Mayola L Nucleic Acids Res. 2004 Jun 4;32(10):3083-92. Print 2004. PMID:15181173<ref>PMID:15181173</ref>
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===NMR Solution Structure of a Parallel LNA Quadruplex===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_15181173}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1s9l]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9L OCA].
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</StructureSection>
[[Category: Esposito, V.]]
[[Category: Esposito, V.]]
[[Category: Mayola, L.]]
[[Category: Mayola, L.]]

Revision as of 08:33, 8 October 2014

NMR Solution Structure of a Parallel LNA Quadruplex

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