1wac

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[[Image:1wac.png|left|200px]]
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==BACK-PRIMING MODE OF PHI6 RNA-DEPENDENT RNA POLYMERASE==
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<StructureSection load='1wac' size='340' side='right' caption='[[1wac]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1wac]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_phage_phi6 Pseudomonas phage phi6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WAC FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hhs|1hhs]], [[1hht|1hht]], [[1hi0|1hi0]], [[1hi1|1hi1]], [[1hi8|1hi8]], [[1uvi|1uvi]], [[1uvj|1uvj]], [[1uvk|1uvk]], [[1uvl|1uvl]], [[1uvm|1uvm]], [[1uvn|1uvn]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wac OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wac RCSB], [http://www.ebi.ac.uk/pdbsum/1wac PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The RNA-dependent RNA polymerase of the double-stranded RNA bacteriophage phi6 is capable of primer-independent initiation, as are many RNA polymerases. The structure of this polymerase revealed an initiation platform, composed of a loop in the C-terminal domain (QYKW, aa 629-632), that was essential for de novo initiation. A similar element has been identified in hepatitis C virus RNA-dependent RNA polymerase. Biochemical studies have addressed the role of this platform, revealing that a mutant version can utilize a back-priming initiation mechanism, where the 3' terminus of the template adopts a hairpin-like conformation. Here, the mechanism of back-primed initiation is studied further by biochemical and structural methods.
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{{STRUCTURE_1wac| PDB=1wac | SCENE= }}
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Back-priming mode of phi6 RNA-dependent RNA polymerase.,Laurila MR, Salgado PS, Stuart DI, Grimes JM, Bamford DH J Gen Virol. 2005 Feb;86(Pt 2):521-6. PMID:15659773<ref>PMID:15659773</ref>
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===BACK-PRIMING MODE OF PHI6 RNA-DEPENDENT RNA POLYMERASE===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_15659773}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1wac]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_phage_phi6 Pseudomonas phage phi6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WAC OCA].
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</StructureSection>
[[Category: Pseudomonas phage phi6]]
[[Category: Pseudomonas phage phi6]]
[[Category: Bamford, D H.]]
[[Category: Bamford, D H.]]

Revision as of 08:34, 8 October 2014

BACK-PRIMING MODE OF PHI6 RNA-DEPENDENT RNA POLYMERASE

1wac, resolution 3.00Å

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