1qzb

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[[Image:1qzb.png|left|200px]]
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==Coordinates of the A-site tRNA model fitted into the cryo-EM map of 70S ribosome in the pre-translocational state==
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<StructureSection load='1qzb' size='340' side='right' caption='[[1qzb]], [[Resolution|resolution]] 9.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qzb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QZB FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ob2|1ob2]], [[1qza|1qza]], [[1qzc|1qzc]], [[1qzd|1qzd]], [[1r2w|1r2w]], [[1r2x|1r2x]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qzb RCSB], [http://www.ebi.ac.uk/pdbsum/1qzb PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Aminoacyl-tRNAs (aa-tRNAs) are delivered to the ribosome as part of the ternary complex of aa-tRNA, elongation factor Tu (EF-Tu) and GTP. Here, we present a cryo-electron microscopy (cryo-EM) study, at a resolution of approximately 9 A, showing that during the incorporation of the aa-tRNA into the 70S ribosome of Escherichia coli, the flexibility of aa-tRNA allows the initial codon recognition and its accommodation into the ribosomal A site. In addition, a conformational change observed in the GTPase-associated center (GAC) of the ribosomal 50S subunit may provide the mechanism by which the ribosome promotes a relative movement of the aa-tRNA with respect to EF-Tu. This relative rearrangement seems to facilitate codon recognition by the incoming aa-tRNA, and to provide the codon-anticodon recognition-dependent signal for the GTPase activity of EF-Tu. From these new findings we propose a mechanism that can explain the sequence of events during the decoding of mRNA on the ribosome.
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{{STRUCTURE_1qzb| PDB=1qzb | SCENE= }}
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Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy.,Valle M, Zavialov A, Li W, Stagg SM, Sengupta J, Nielsen RC, Nissen P, Harvey SC, Ehrenberg M, Frank J Nat Struct Biol. 2003 Nov;10(11):899-906. Epub 2003 Oct 19. PMID:14566331<ref>PMID:14566331</ref>
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===Coordinates of the A-site tRNA model fitted into the cryo-EM map of 70S ribosome in the pre-translocational state===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_14566331}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1qzb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZB OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:014566331</ref><references group="xtra"/>
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[[Category: Ehrenberg, M.]]
[[Category: Ehrenberg, M.]]
[[Category: Frank, J.]]
[[Category: Frank, J.]]

Revision as of 08:34, 8 October 2014

Coordinates of the A-site tRNA model fitted into the cryo-EM map of 70S ribosome in the pre-translocational state

1qzb, resolution 9.00Å

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