3hk0

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{{Seed}}
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==Crystal Structure of the RA and PH Domains of Grb10==
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[[Image:3hk0.jpg|left|200px]]
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<StructureSection load='3hk0' size='340' side='right' caption='[[3hk0]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3hk0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HK0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HK0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GRB10, GRBIR, KIAA0207 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hk0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hk0 RCSB], [http://www.ebi.ac.uk/pdbsum/3hk0 PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/3hk0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Growth factor receptor-binding proteins Grb7, Grb10 and Grb14 are adaptor proteins containing a Ras-associating (RA) domain, a pleckstrin-homology (PH) domain, a family-specific BPS (between PH and SH2) region and a C-terminal Src-homology-2 domain. Previous structural studies showed that the Grb14 BPS region binds as a pseudosubstrate inhibitor in the tyrosine kinase domain of the insulin receptor to suppress insulin signaling. Here we report the crystal structure of the RA and PH domains of Grb10 at 2.6-A resolution. The structure reveals that these two domains, along with the intervening linker, form an integrated, dimeric structural unit. Biochemical studies demonstrated that Grb14 binds to activated Ras, which may serve as a timing mechanism for downregulation of insulin signaling. Our results illuminate the membrane-recruitment mechanisms not only of Grb7, Grb10 and Grb14 but also of MIG-10, Rap1-interacting adaptor molecule, lamellipodin and Pico, proteins involved in actin-cytoskeleton rearrangement that share a structurally related RA-PH tandem unit.
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Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14.,Depetris RS, Wu J, Hubbard SR Nat Struct Mol Biol. 2009 Aug;16(8):833-9. Epub 2009 Aug 2. PMID:19648926<ref>PMID:19648926</ref>
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The line below this paragraph, containing "STRUCTURE_3hk0", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3hk0| PDB=3hk0 | SCENE= }}
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===Crystal Structure of the RA and PH Domains of Grb10===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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<!--
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*[[Growth factor receptor-bound protein|Growth factor receptor-bound protein]]
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The line below this paragraph, {{ABSTRACT_PUBMED_19648926}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 19648926 is the PubMed ID number.
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<references/>
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-->
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__TOC__
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{{ABSTRACT_PUBMED_19648926}}
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</StructureSection>
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==About this Structure==
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3HK0 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HK0 OCA].
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==Reference==
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<ref group="xtra">PMID:19648926</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Depetris, R S.]]
[[Category: Depetris, R S.]]
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[[Category: Wu, J.]]
[[Category: Wu, J.]]
[[Category: Adapter protein]]
[[Category: Adapter protein]]
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[[Category: Alternative splicing]]
 
[[Category: Grb10]]
[[Category: Grb10]]
[[Category: Ph]]
[[Category: Ph]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Pleckstrin-homology]]
[[Category: Pleckstrin-homology]]
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[[Category: Polymorphism]]
 
[[Category: Ra]]
[[Category: Ra]]
[[Category: Ras-associating]]
[[Category: Ras-associating]]
[[Category: Sh2 domain]]
[[Category: Sh2 domain]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 19 13:02:55 2009''
 

Revision as of 05:41, 10 October 2014

Crystal Structure of the RA and PH Domains of Grb10

3hk0, resolution 2.60Å

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