1jk8

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[[Image:1jk8.jpg|left|200px]]<br /><applet load="1jk8" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1jk8.jpg|left|200px]]
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caption="1jk8, resolution 2.40&Aring;" />
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'''Crystal structure of a human insulin peptide-HLA-DQ8 complex'''<br />
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{{Structure
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|PDB= 1jk8 |SIZE=350|CAPTION= <scene name='initialview01'>1jk8</scene>, resolution 2.40&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of a human insulin peptide-HLA-DQ8 complex'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1JK8 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JK8 OCA].
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1JK8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JK8 OCA].
==Reference==
==Reference==
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Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes., Lee KH, Wucherpfennig KW, Wiley DC, Nat Immunol. 2001 Jun;2(6):501-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11376336 11376336]
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Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes., Lee KH, Wucherpfennig KW, Wiley DC, Nat Immunol. 2001 Jun;2(6):501-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11376336 11376336]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: type 1 diabetes]]
[[Category: type 1 diabetes]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:23:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:04:31 2008''

Revision as of 10:04, 20 March 2008

Image:1jk8.jpg


PDB ID 1jk8

Drag the structure with the mouse to rotate
, resolution 2.40Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



Crystal structure of a human insulin peptide-HLA-DQ8 complex


Contents

Overview

The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8 and HLA-DQ2 in humans and I-A(g7) in nonobese diabetic (NOD) mice are the major risk factors for increased susceptibility to type 1 diabetes. Using X-ray crystallography, we have determined the three-dimensional structure of DQ8 complexed with an immunodominant peptide from insulin. The similarity of the DQ8, DQ2 and I-A(g7) peptide-binding pockets suggests that diabetes is caused by the same antigen-presentation event(s) in humans and NOD mice. Correlating type 1 diabetes epidemiology and MHC sequences with the DQ8 structure suggests that other structural features of the P9 pocket in addition to position 57 contribute to susceptibility to type 1 diabetes.

Disease

Known diseases associated with this structure: Celiac disease, susceptibility to OMIM:[146880], Diabetes mellitus, rare form OMIM:[176730], Hyperproinsulinemia, familial OMIM:[176730], MODY, one form OMIM:[176730]

About this Structure

1JK8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes., Lee KH, Wucherpfennig KW, Wiley DC, Nat Immunol. 2001 Jun;2(6):501-7. PMID:11376336

Page seeded by OCA on Thu Mar 20 12:04:31 2008

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