2jja

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[[Image:2jja.png|left|200px]]
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==CRYSTAL STRUCTURE OF GNA WITH SYNTHETIC COPPER BASE PAIR==
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<StructureSection load='2jja' size='340' side='right' caption='[[2jja]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2jja]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JJA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZAD:(S)-1-(2,3-DIHYDROXYPROPYL)-ADENINE'>ZAD</scene>, <scene name='pdbligand=ZCY:(S)-1-(2,3-DIHYDROXYPROPYL)-CYTOSINE'>ZCY</scene>, <scene name='pdbligand=ZGU:(S)-1-(2,3-DIHYDROXYPROPYL)-GUANINE'>ZGU</scene>, <scene name='pdbligand=ZHP:(S)-1-(2,3-DIHYDROXYPROPYL)-HYDROXYPYRIDONE'>ZHP</scene>, <scene name='pdbligand=ZTH:(S)-1-(2,3-DIHYDROXYPROPYL)-THYMINE'>ZTH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jja OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jja RCSB], [http://www.ebi.ac.uk/pdbsum/2jja PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of an 8-mer (S)-GNA duplex is presented. As a tool for phasing, the anomalous diffraction of two copper(II) ions within two artificial metallo-base pairs was employed. The duplex structure confirms a canonical Watson-Crick base pairing scheme of GNA with antiparallel strands. The duplex secondary structure is distinct from canonical A- and B-form nucleic acids and can be described as a right-handed helical ribbon wrapped around the helix axis, resulting in a large hollow core. Most intriguingly, neighboring base pairs slide strongly against each other, resulting in extensive interstrand base-base hydrophobic interactions along with unusual hydrophobic intrastrand interactions of nucleobases with their backbone. These results reveal how a minimal nucleic acid backbone can support highly stable Watson-Crick-like duplex formation.
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{{STRUCTURE_2jja| PDB=2jja | SCENE= }}
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Duplex structure of a minimal nucleic acid.,Schlegel MK, Essen LO, Meggers E J Am Chem Soc. 2008 Jul 2;130(26):8158-9. Epub 2008 Jun 5. PMID:18529005<ref>PMID:18529005</ref>
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===CRYSTAL STRUCTURE OF GNA WITH SYNTHETIC COPPER BASE PAIR===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_18529005}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2jja]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JJA OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:018529005</ref><references group="xtra"/>
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[[Category: Essen, L O.]]
[[Category: Essen, L O.]]
[[Category: Meggers, E.]]
[[Category: Meggers, E.]]

Revision as of 15:26, 12 October 2014

CRYSTAL STRUCTURE OF GNA WITH SYNTHETIC COPPER BASE PAIR

2jja, resolution 1.30Å

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