2h0p

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[[Image:2h0p.png|left|200px]]
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==NMR Structure of the Dengue-4 virus Envelope Protein Domain III==
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<StructureSection load='2h0p' size='340' side='right' caption='[[2h0p]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2h0p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H0P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H0P FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h0p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h0p RCSB], [http://www.ebi.ac.uk/pdbsum/2h0p PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The disease dengue (DEN) is caused by four serologically related viruses termed DEN1, DEN2, DEN3 and DEN4. The structure of the ectodomain of the envelope protein has been determined previously for DEN2 and DEN3 viruses. Using NMR spectroscopic methods, we solved the solution structure of domain III (ED3), the receptor-binding domain, of the envelope protein of DEN4 virus, human strain 703-4. The structure shows that the nine amino acid changes in ED3 that separate the sylvatic and human DEN4 strains are surface exposed. Important structural differences between DEN4-rED3 and ED3 domains of DEN2, DEN3 and other flaviviruses are discussed.
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{{STRUCTURE_2h0p| PDB=2h0p | SCENE= }}
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Solution structure of the envelope protein domain III of dengue-4 virus.,Volk DE, Lee YC, Li X, Thiviyanathan V, Gromowski GD, Li L, Lamb AR, Beasley DW, Barrett AD, Gorenstein DG Virology. 2007 Jul 20;364(1):147-54. Epub 2007 Mar 29. PMID:17395234<ref>PMID:17395234</ref>
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===NMR Structure of the Dengue-4 virus Envelope Protein Domain III===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_17395234}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2h0p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H0P OCA].
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</StructureSection>
[[Category: Dengue virus 4]]
[[Category: Dengue virus 4]]
[[Category: Barrett, A D.T.]]
[[Category: Barrett, A D.T.]]

Revision as of 15:28, 12 October 2014

NMR Structure of the Dengue-4 virus Envelope Protein Domain III

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