2g9l

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[[Image:2g9l.png|left|200px]]
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==The High-resolution Solution Conformation of an Antimicrobial Peptide Gaegurin 4 and Its Mode of Membrane Interaction==
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<StructureSection load='2g9l' size='340' side='right' caption='[[2g9l]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2g9l]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G9L FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2g9l RCSB], [http://www.ebi.ac.uk/pdbsum/2g9l PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have applied NMR spectroscopy to determine the high-resolution structure of gaegurin 4, a 37-residue antimicrobial peptide from Rana rugosa, under varying hydrophobic conditions. Even in 100% H2O, gaegurin 4 contains a nascent turn near its C-terminal Rana box. Under a more hydrophobic condition it forms two amphipathic helices, one long encompassing residues 2-23 and the other consisting of residues 25-34, similar to what has been observed in cecropin A. Functional implication of the helix-breaking kink at Gly24 in gaegurin 4 was investigated by preparing several analogs. Based upon the current and previous results, we propose a novel seaanemone-like ion pore-forming model for gaegurin 4.
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{{STRUCTURE_2g9l| PDB=2g9l | SCENE= }}
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Solution structure and membrane interaction mode of an antimicrobial peptide gaegurin 4.,Chi SW, Kim JS, Kim DH, Lee SH, Park YH, Han KH Biochem Biophys Res Commun. 2007 Jan 19;352(3):592-7. Epub 2006 Nov 27. PMID:17141187<ref>PMID:17141187</ref>
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===The High-resolution Solution Conformation of an Antimicrobial Peptide Gaegurin 4 and Its Mode of Membrane Interaction===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_17141187}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2g9l]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9L OCA].
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</StructureSection>
[[Category: Chi, S W.]]
[[Category: Chi, S W.]]
[[Category: Han, K H.]]
[[Category: Han, K H.]]
[[Category: Amphipathic helix]]
[[Category: Amphipathic helix]]
[[Category: Antibiotic]]
[[Category: Antibiotic]]

Revision as of 15:32, 12 October 2014

The High-resolution Solution Conformation of an Antimicrobial Peptide Gaegurin 4 and Its Mode of Membrane Interaction

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