2km3

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[[Image:2km3.png|left|200px]]
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==Structure of an intramolecular G-quadruplex containing a G.C.G.C tetrad formed by human telomeric variant CTAGGG repeats==
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<StructureSection load='2km3' size='340' side='right' caption='[[2km3]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2km3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KM3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KM3 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[143d|143d]], [[1k8p|1k8p]], [[2aqy|2aqy]], [[2gku|2gku]], [[2jsk|2jsk]], [[2jsl|2jsl]], [[2jsm|2jsm]], [[2jsq|2jsq]], [[2kf7|2kf7]], [[2kf8|2kf8]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2km3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2km3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2km3 RCSB], [http://www.ebi.ac.uk/pdbsum/2km3 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Short contiguous arrays of variant CTAGGG repeats in the human telomere are unstable in the male germline and somatic cells, suggesting formation of unusual structures by this repeat type. Here, we report on the structure of an intramolecular G-quadruplex formed by DNA sequences containing four human telomeric variant CTAGGG repeats in potassium solution. Our results reveal a new robust antiparallel G-quadruplex fold involving two G-tetrads sandwiched between a G.C base pair and a G.C.G.C tetrad, which could represent a new platform for drug design targeted to human telomeric DNA.
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{{STRUCTURE_2km3| PDB=2km3 | SCENE= }}
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Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad.,Lim KW, Alberti P, Guedin A, Lacroix L, Riou JF, Royle NJ, Mergny JL, Phan AT Nucleic Acids Res. 2009 Oct;37(18):6239-48. Epub 2009 Aug 19. PMID:19692585<ref>PMID:19692585</ref>
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===Structure of an intramolecular G-quadruplex containing a G.C.G.C tetrad formed by human telomeric variant CTAGGG repeats===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19692585}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2km3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KM3 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019692585</ref><references group="xtra"/>
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[[Category: Alberti, P.]]
[[Category: Alberti, P.]]
[[Category: Guedin, A.]]
[[Category: Guedin, A.]]

Revision as of 15:32, 12 October 2014

Structure of an intramolecular G-quadruplex containing a G.C.G.C tetrad formed by human telomeric variant CTAGGG repeats

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