2kbp

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[[Image:2kbp.png|left|200px]]
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==Solution structure of a G-quadruplex of human telomeric RNA==
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<StructureSection load='2kbp' size='340' side='right' caption='[[2kbp]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kbp]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KBP FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kbp RCSB], [http://www.ebi.ac.uk/pdbsum/2kbp PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Very recent studies showed that mammalian telomeres were transcribed into telomeric-repeat-containing RNAs and suggested that these RNA molecules were biologically important. Here we report on a structural study of RNA G-quadruplexes formed by human telomeric RNA sequences in K(+) solution. Our data indicated that these sequences formed propeller-type parallel-stranded RNA G-quadruplexes. We have determined the NMR-based solution structure of a dimeric propeller-type RNA G-quadruplex formed by the 12-nt human telomeric RNA sequence r(UAGGGUUAGGGU). We also observed the stacking of two such propeller-type G-quadruplex blocks for the 10-nt human telomeric RNA sequence r(GGGUUAGGGU) and a higher-order G-quadruplex structure for the 9-nt human telomeric RNA sequence r(GGGUUAGGG). Based on these findings we proposed how higher-order structures might be formed by long telomeric RNA.
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{{STRUCTURE_2kbp| PDB=2kbp | SCENE= }}
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Structure of propeller-type parallel-stranded RNA G-quadruplexes, formed by human telomeric RNA sequences in K+ solution.,Martadinata H, Phan AT J Am Chem Soc. 2009 Feb 25;131(7):2570-8. PMID:19183046<ref>PMID:19183046</ref>
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===Solution structure of a G-quadruplex of human telomeric RNA===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19183046}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2kbp]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBP OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019183046</ref><references group="xtra"/>
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[[Category: Martadinata, H.]]
[[Category: Martadinata, H.]]
[[Category: Phan, A T.]]
[[Category: Phan, A T.]]

Revision as of 15:34, 12 October 2014

Solution structure of a G-quadruplex of human telomeric RNA

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