2jo5

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[[Image:2jo5.png|left|200px]]
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==Tetrameric structure of KIA7F peptide==
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<StructureSection load='2jo5' size='340' side='right' caption='[[2jo5]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2jo5]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JO5 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jo4|2jo4]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jo5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jo5 RCSB], [http://www.ebi.ac.uk/pdbsum/2jo5 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Can unique protein structures arise from a limited set of amino acids present on the prebiotic earth? To address this question, we have determined the stability and structure of KIA7, a 20-residue polypeptide containing chiefly Lys, Ile, and Ala. NMR methods reveal that KIA7 tetramerizes and folds on the millisecond time scale to adopt a four-helix X-bundle structure with a tightly and specifically packed core. Denaturation studies and hydrogen exchange measurements of KIA7 and several variants demonstrate that ridges-into-grooves packing of Ala and Ile side chains and the packing of a C-terminal aromatic group into the hydrophobic core are sufficient to give rise to a rather stable, well folded protein structure, with no favorable electrostatic interactions or tertiary or quaternary hydrogen bonds. Both modern proteins and RNAs can adopt specific structures, but RNAs do so with a limited "alphabet" of residues and types of stabilizing interactions. The results reported here show that specific, well folded protein structures can also arise from a highly reduced set of stabilizing interactions and amino acids that are thought to have been present on the prebiotic earth.
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{{STRUCTURE_2jo5| PDB=2jo5 | SCENE= }}
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Getting specificity from simplicity in putative proteins from the prebiotic earth.,Lopez de la Osa J, Bateman DA, Ho S, Gonzalez C, Chakrabartty A, Laurents DV Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14941-6. Epub 2007 Sep 12. PMID:17855563<ref>PMID:17855563</ref>
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===Tetrameric structure of KIA7F peptide===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_17855563}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2jo5]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JO5 OCA].
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</StructureSection>
[[Category: Bateman, D A.]]
[[Category: Bateman, D A.]]
[[Category: Chakrabartty, A.]]
[[Category: Chakrabartty, A.]]

Revision as of 15:34, 12 October 2014

Tetrameric structure of KIA7F peptide

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