2jym

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[[Image:2jym.png|left|200px]]
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==Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element==
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<StructureSection load='2jym' size='340' side='right' caption='[[2jym]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2jym]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JYM FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jym OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jym RCSB], [http://www.ebi.ac.uk/pdbsum/2jym PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Chronic hepatitis B virus (HBV) infections may lead to severe diseases like liver cirrhosis or hepatocellular carcinoma (HCC). The HBV post-transcriptional regulatory element (HPRE) facilitates the nuclear export of unspliced viral mRNAs, contains a splicing regulatory element and resides in the 3'-region of all viral transcripts. The HPRE consists of three sub-elements alpha (nucleotides 1151-1346), beta1 (nucleotides 1347-1457) and beta2 (nucleotides 1458-1582), which confer together full export competence. Here, we present the NMR solution structure (pdb 2JYM) of the stem-loop alpha (SLalpha, nucleotides 1292-1321) located in the sub-element alpha. The SLalpha contains a CAGGC pentaloop highly conserved in hepatoviruses, which essentially adopts a CUNG-like tetraloop conformation. Furthermore, the SLalpha harbours a single bulged G residue flanked by A-helical regions. The structure is highly suggestive of serving two functions in the context of export of unspliced viral RNA: binding sterile alpha motif (SAM-) domain containing proteins and/or preventing the utilization of a 3'-splice site contained within SLalpha.
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{{STRUCTURE_2jym| PDB=2jym | SCENE= }}
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Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element.,Schwalbe M, Ohlenschlager O, Marchanka A, Ramachandran R, Hafner S, Heise T, Gorlach M Nucleic Acids Res. 2008 Mar;36(5):1681-9. Epub 2008 Feb 7. PMID:18263618<ref>PMID:18263618</ref>
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===Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_18263618}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2jym]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JYM OCA].
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</StructureSection>
[[Category: Gorlach, M.]]
[[Category: Gorlach, M.]]
[[Category: Ohlenschlager, O.]]
[[Category: Ohlenschlager, O.]]

Revision as of 15:36, 12 October 2014

Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element

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