1jmm
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1jmm.jpg|left|200px]] | + | [[Image:1jmm.jpg|left|200px]] |
| - | + | ||
| - | '''Crystal structure of the V-region of Streptococcus mutans antigen I/II''' | + | {{Structure |
| + | |PDB= 1jmm |SIZE=350|CAPTION= <scene name='initialview01'>1jmm</scene>, resolution 2.40Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NA:SODIUM ION'>NA</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of the V-region of Streptococcus mutans antigen I/II''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1JMM is a [ | + | 1JMM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JMM OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the V-region of Streptococcus mutans antigen I/II at 2.4 A resolution suggests a sugar preformed binding site., Troffer-Charlier N, Ogier J, Moras D, Cavarelli J, J Mol Biol. 2002 Apr 19;318(1):179-88. PMID:[http:// | + | Crystal structure of the V-region of Streptococcus mutans antigen I/II at 2.4 A resolution suggests a sugar preformed binding site., Troffer-Charlier N, Ogier J, Moras D, Cavarelli J, J Mol Biol. 2002 Apr 19;318(1):179-88. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12054777 12054777] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Streptococcus mutans]] | [[Category: Streptococcus mutans]] | ||
| Line 21: | Line 30: | ||
[[Category: v-region]] | [[Category: v-region]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:05:25 2008'' |
Revision as of 10:05, 20 March 2008
| |||||||
| , resolution 2.40Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the V-region of Streptococcus mutans antigen I/II
Overview
Antigens I/II are large multifunctional adhesins from oral viridans streptococci that exert immunomodulatory effects on human cells and play important roles in inflammatory disorders. Among them, Streptococcus mutans plays a major role in the initiation of dental caries. The structure of the V-region (SrV+, residues 464-840) of the antigen I/II of S. mutans has been determined using the multiwavelength anomalous diffraction phasing technique with seleno-methionine-substituted recombinant protein and subsequently refined at 2.4 A resolution. The crystal structure of SrV+ revealed a lectin-like fold that displays a putative preformed carbohydrate-binding site stabilized by a metal ion. Inhibition of this binding site may confer to humans a protection against dental caries and dissemination of the bacteria to extra-oral sites involved in life-threatening inflammatory diseases. This crystal structure constitutes a first step in understanding the structure-function relationship of antigens I/II and may help in delineating new preventive or therapeutic strategies against colonization of the host by oral streptococci.
About this Structure
1JMM is a Single protein structure of sequence from Streptococcus mutans. Full crystallographic information is available from OCA.
Reference
Crystal structure of the V-region of Streptococcus mutans antigen I/II at 2.4 A resolution suggests a sugar preformed binding site., Troffer-Charlier N, Ogier J, Moras D, Cavarelli J, J Mol Biol. 2002 Apr 19;318(1):179-88. PMID:12054777
Page seeded by OCA on Thu Mar 20 12:05:25 2008
