Sandbox ceg1p Steven Paris

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Function of Ceg1p and the Cet1-Ceg1 mRNA Capping Complex

Ceg1p is an mRNA guanylyltransferase in Saccharomyces cerevisiae that forms a heterotetramer with the RNA triphosphatase cet1p which is called the mRNA capping apparatus. This complex is recruited by RNA polymerase II (RNAP-II) and performs the first two steps in the 5’-guanisine capping mechanism of mRNA. Cet1p hydrolyzes the 5’-triphosphate end of the mRNA, then Ceg1p attaches a guanine monophosphate (GMP) to the 5’-diphosphate end (1).

Structure of Ceg1p and Interactions with Cet1p in the Capping Apparatus

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Structural highlights

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