VP24
From Proteopedia
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There are a few structural characteristics only found in the Ebola viruses. At the top of the pyramidal domain, there are α helices present which are thought to interact with the α karyopherin(1). An α helix formed by the N-terminus runs from the top of the "pyramid" to another nearby VP24, where it binds to one of the pockets located underneath the "pyramid"(1). | There are a few structural characteristics only found in the Ebola viruses. At the top of the pyramidal domain, there are α helices present which are thought to interact with the α karyopherin(1). An α helix formed by the N-terminus runs from the top of the "pyramid" to another nearby VP24, where it binds to one of the pockets located underneath the "pyramid"(1). | ||
| - | <scene name='60/602719/Marburg_vp24_domain/1'>Marburg | + | <scene name='60/602719/Marburg_vp24_domain/1'>Marburg Domain</scene> |
The Marburg domain has two beta strands present that stick out from the structure(1). The Marburg VP24 doesn't use an alpha helix to bind to another VP24 like the Ebola VP24(1). Instead, it uses a flexible strand that binds to a groove of a close-by VP24(1). | The Marburg domain has two beta strands present that stick out from the structure(1). The Marburg VP24 doesn't use an alpha helix to bind to another VP24 like the Ebola VP24(1). Instead, it uses a flexible strand that binds to a groove of a close-by VP24(1). | ||
Revision as of 03:10, 14 October 2014
VP24
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References
1. Zhang, A.P.P., Bornholdt, Z.A., Abelson, D.M., Saphire, E.O. Crystal Structure of Marburg Virus VP24. J. Virol.2014, Feb 26;88(10):5859
2. Zhang, P.P., Abelson, D.M., Bornholdt, Z.A., Liu, T., Woods, V.L. Jr., Saphire, E. O. The ebolavirus VP24 interferon antagonist: Know your enemy. Virulence. 2012, Aug 15;3(5)440-445
3. Xu, W., Edwards, M.R., Borek, D.M., Feagins, A.R., Mittal, A., Alinger, J.B., Berry, K.N., Yen, B., Hamilton, J., Brett, T.J., Pappu, R.V., Leung, D.W., Basler, C.F., Amarasinghe, G.K. Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1. Cell Host & Microbe. 2014, Aug 13;16 187-200
4. Edwards, R. M., Johnson, B., Mire, C.E., Xu, W., Shabman, R.S., Speller, L.N., Leung, D.W., Geisbert, T.W., Amarasinghe, G.K., Basler, C.F. The Marburg Virus VP24 Protein Interacts with Keap1 to Activate the Cytoprotective Antioxidant Response Pathway. Cell. 2014, Mar 27. 6 1017-1025
5. Bharat, T.A.M., Noda, T., Riches, J.D., Kraehling, V., Kolesnikova, L., Becker, S., Kawaoka, Y., Briggs, J.A.G. Structural dissection of Ebola virus and its assembly determinants using cryo-electron tomography. PNAS. 2012, Feb 6 109(11) 4275-4280.
