Sandbox SRp20 John Davis
From Proteopedia
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==Structure== | ==Structure== | ||
<StructureSection load='2i2y' size='340' side='right' caption='[[SRp20]], [[NMR_Ensembles_of_Models | 28 NMR models]]' scene=''> | <StructureSection load='2i2y' size='340' side='right' caption='[[SRp20]], [[NMR_Ensembles_of_Models | 28 NMR models]]' scene=''> | ||
| - | SRp20 is one of the smallest members of Ser- and Arg-rich protein family | + | SRp20 is one of the smallest members of Ser- and Arg-rich protein family with 150 amino acids in the protein. The RNA recognition motif (RRM)of SRp20 has a βαββαβ topology, with two α-helices packed against one side of the four-stranded <scene name='60/602705/Entire_rrm/1'>β-sheet</scene>. The β-sheet surface has a large hydrophobic core with the aromatic amino acids Tyr, Phe, and Trp. The aromatic amino acid residues in the β-sheet are what cause the affinity of RNA for SRp20. When RNA binds to to SRp20, 3-8 nucleotides in the RNA bind to the four-stranded β-sheet in the <scene name='60/602705/Rrm/1'>RRM</scene>. TAP binds to the <scene name='60/602705/New_tap_site/1'>Arg-rich</scene> α-helices that are opposite the β-sheet in the RRM. So, RNA binds to one side of the RRM and TAP binds to the other.(1) |
== Function == | == Function == | ||
| - | + | SRp20 is important for alternative RNA splicing. SRp20 can work with the C-terminal domain (CTD) of RNA pol II to remove exons from RNA after transcription. A mechanism for this has not been proposed, however it is clear that the CTD and SRp20 must be present in order for alternative splicing of some exons to occur. (2) | |
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
| - | == Structural highlights == | ||
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| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 05:44, 14 October 2014
Structure
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