2lwk
From Proteopedia
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| - | + | ==Solution structure of small molecule-influenza RNA complex== | |
| - | + | <StructureSection load='2lwk' size='340' side='right' caption='[[2lwk]], [[NMR_Ensembles_of_Models | 16 NMR models]]' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2lwk]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LWK FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0EC:6,7-DIMETHOXY-2-(PIPERAZIN-1-YL)QUINAZOLIN-4-AMINE'>0EC</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lwk RCSB], [http://www.ebi.ac.uk/pdbsum/2lwk PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Through screening by NMR spectroscopy, we discovered a novel scaffold (DPQ: 6,7-dimethoxy-2-(1-piperazinyl)-4-quinazolinamine) that binds specifically to the influenza A virus RNA promoter. The solution structure of the RNA-DPQ complex reported here demonstrates that the internal loop is the binding site of DPQ. The scaffold exhibits antiviral activity against influenza viruses. | ||
| - | + | A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication.,Lee MK, Bottini A, Kim M, Bardaro MF Jr, Zhang Z, Pellecchia M, Choi BS, Varani G Chem Commun (Camb). 2014 Jan 11;50(3):368-70. doi: 10.1039/c3cc46973e. Epub 2013 , Nov 18. PMID:24247110<ref>PMID:24247110</ref> | |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Choi, B S.]] | [[Category: Choi, B S.]] | ||
[[Category: Lee, M K.]] | [[Category: Lee, M K.]] | ||
Revision as of 08:32, 20 October 2014
Solution structure of small molecule-influenza RNA complex
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