1jnx
From Proteopedia
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| - | [[Image:1jnx.gif|left|200px]] | + | [[Image:1jnx.gif|left|200px]] |
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| - | '''Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1''' | + | {{Structure |
| + | |PDB= 1jnx |SIZE=350|CAPTION= <scene name='initialview01'>1jnx</scene>, resolution 2.5Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NI:NICKEL (II) ION'>NI</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= BRCA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1JNX is a [ | + | 1JNX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNX OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1., Williams RS, Green R, Glover JN, Nat Struct Biol. 2001 Oct;8(10):838-42. PMID:[http:// | + | Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1., Williams RS, Green R, Glover JN, Nat Struct Biol. 2001 Oct;8(10):838-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11573086 11573086] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: gene expression]] | [[Category: gene expression]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:05:59 2008'' |
Revision as of 10:06, 20 March 2008
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| , resolution 2.5Å | |||||||
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| Ligands: | |||||||
| Gene: | BRCA1 (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1
Contents |
Overview
The C-terminal BRCT region of BRCA1 is essential for its DNA repair, transcriptional regulation and tumor suppressor functions. Here we determine the crystal structure of the BRCT domain of human BRCA1 at 2.5 A resolution. The domain contains two BRCT repeats that adopt similar structures and are packed together in a head-to-tail arrangement. Cancer-causing missense mutations occur at the interface between the two repeats and destabilize the structure. The manner by which the two BRCT repeats interact in BRCA1 may represent a general mode of interaction between homologous domains within proteins that interact to regulate the cellular response to DNA damage. The structure provides a basis to predict the structural consequences of uncharacterized BRCA1 mutations.
Disease
Known diseases associated with this structure: Breast cancer-1 OMIM:[113705], Breast-ovarian cancer OMIM:[113705], Ovarian cancer OMIM:[113705], Papillary serous carcinoma of the peritoneum OMIM:[113705]
About this Structure
1JNX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1., Williams RS, Green R, Glover JN, Nat Struct Biol. 2001 Oct;8(10):838-42. PMID:11573086
Page seeded by OCA on Thu Mar 20 12:05:59 2008
Categories: Homo sapiens | Single protein | Glover, J N.M. | Green, R. | Williams, R S. | NI | Brct | Cancer | Gene expression
