4r6u
From Proteopedia
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| - | ''' | + | ==IL-18 receptor complex== |
| + | <StructureSection load='4r6u' size='340' side='right' caption='[[4r6u]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4r6u]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R6U FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r6u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r6u RCSB], [http://www.ebi.ac.uk/pdbsum/4r6u PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Interleukin 18 (IL-18), a member of the IL-1 family of cytokines, is an important regulator of innate and acquired immune responses. It signals through its ligand-binding primary receptor IL-18Ralpha and accessory receptor IL-18Rbeta. Here we report the crystal structure of IL-18 with the ectodomain of IL-18Ralpha, which reveals the structural basis for their specific recognition. It confirms that surface charge complementarity determines the ligand-binding specificity of primary receptors in the IL-1 receptor family. We suggest that IL-18 signaling complex adopts an architecture similar to other agonistic cytokines and propose a general ligand-receptor assembly and activation model for the IL-1 family. | ||
| - | + | Structural basis for the specific recognition of IL-18 by its alpha receptor.,Wei H, Wang D, Qian Y, Liu X, Fan S, Yin HS, Wang X FEBS Lett. 2014 Sep 26. pii: S0014-5793(14)00696-6. doi:, 10.1016/j.febslet.2014.09.019. PMID:25261253<ref>PMID:25261253</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Wang, X.]] | ||
| + | [[Category: Wei, H.]] | ||
| + | [[Category: Beta-trefoil fold]] | ||
| + | [[Category: Ig-like fold]] | ||
| + | [[Category: Immune system]] | ||
Revision as of 10:36, 20 October 2014
IL-18 receptor complex
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