1jr1

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[[Image:1jr1.jpg|left|200px]]<br /><applet load="1jr1" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1jr1.jpg|left|200px]]
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caption="1jr1, resolution 2.6&Aring;" />
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'''Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid'''<br />
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{{Structure
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|PDB= 1jr1 |SIZE=350|CAPTION= <scene name='initialview01'>1jr1</scene>, resolution 2.6&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene> and <scene name='pdbligand=MOA:MYCOPHENOLIC ACID'>MOA</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205]
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|GENE=
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}}
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'''Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1JR1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus] with <scene name='pdbligand=K:'>K</scene>, <scene name='pdbligand=IMP:'>IMP</scene> and <scene name='pdbligand=MOA:'>MOA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA].
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1JR1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA].
==Reference==
==Reference==
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Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid., Sintchak MD, Fleming MA, Futer O, Raybuck SA, Chambers SP, Caron PR, Murcko MA, Wilson KP, Cell. 1996 Jun 14;85(6):921-30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8681386 8681386]
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Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid., Sintchak MD, Fleming MA, Futer O, Raybuck SA, Chambers SP, Caron PR, Murcko MA, Wilson KP, Cell. 1996 Jun 14;85(6):921-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8681386 8681386]
[[Category: Cricetulus griseus]]
[[Category: Cricetulus griseus]]
[[Category: IMP dehydrogenase]]
[[Category: IMP dehydrogenase]]
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[[Category: mycophenolic acid]]
[[Category: mycophenolic acid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:25:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:07:16 2008''

Revision as of 10:07, 20 March 2008

Image:1jr1.jpg


PDB ID 1jr1

Drag the structure with the mouse to rotate
, resolution 2.6Å
Ligands: , and
Activity: IMP dehydrogenase, with EC number 1.1.1.205
Coordinates: save as pdb, mmCIF, xml



Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid


Overview

The structure of inosine-5'-monophosphate dehydrogenase (IMPDH) in complex with IMP and mycophenolic acid (MPA) has been determined by X-ray diffraction. IMPDH plays a central role in B and T lymphocyte replication. MPA is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug recently approved for the treatment of allograft rejection. IMPDH comprises two domains: a core domain, which is an alpha/beta barrel and contains the active site, and a flanking domain. The complex, in combination with mutagenesis and kinetic data, provides a structural basis for understanding the mechanism of IMPDH activity and indicates that MPA inhibits IMPDH by acting as a replacement for the nicotinamide portion of the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule.

About this Structure

1JR1 is a Single protein structure of sequence from Cricetulus griseus. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid., Sintchak MD, Fleming MA, Futer O, Raybuck SA, Chambers SP, Caron PR, Murcko MA, Wilson KP, Cell. 1996 Jun 14;85(6):921-30. PMID:8681386

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