This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4rg2
From Proteopedia
(Difference between revisions)
m (Protected "4rg2" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | ''' | + | ==Tudor Domain of Tumor suppressor p53BP1 with small molecule ligand== |
| - | + | <StructureSection load='4rg2' size='340' side='right' caption='[[4rg2]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4rg2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RG2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3OO:3-BROMO-N-[3-(TERT-BUTYLAMINO)PROPYL]BENZAMIDE'>3OO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rg2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rg2 RCSB], [http://www.ebi.ac.uk/pdbsum/4rg2 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN]] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H.]] | ||
| + | [[Category: Bountra, C.]] | ||
| + | [[Category: Brown, P J.]] | ||
| + | [[Category: Dong, A.]] | ||
| + | [[Category: Edwards, A M.]] | ||
| + | [[Category: Frye, S.]] | ||
| + | [[Category: James, L.]] | ||
| + | [[Category: Mader, P.]] | ||
| + | [[Category: Perfetti, M.]] | ||
| + | [[Category: SGC, Structural Genomics Consortium.]] | ||
| + | [[Category: Tempel, W.]] | ||
| + | [[Category: 53bp1 tudor]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Structural genomics consortium]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 11:03, 20 October 2014
Tudor Domain of Tumor suppressor p53BP1 with small molecule ligand
| |||||||||||
