4v06
From Proteopedia
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| - | ''' | + | ==Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain== |
| + | <StructureSection load='4v06' size='340' side='right' caption='[[4v06]], [[Resolution|resolution]] 2.63Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4v06]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V06 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V06 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_5-monooxygenase Tryptophan 5-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.4 1.14.16.4] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v06 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v06 RCSB], [http://www.ebi.ac.uk/pdbsum/4v06 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TPH2_HUMAN TPH2_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders. | ||
| + | == Function == | ||
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Tryptophan 5-monooxygenase]] | |
| - | + | [[Category: Arrowsmith, C.]] | |
| - | + | [[Category: Bountra, C.]] | |
| + | [[Category: Burgess-Brown, N.]] | ||
| + | [[Category: Delft, F von.]] | ||
| + | [[Category: Edwards, A.]] | ||
| + | [[Category: Fitzpatrick, F.]] | ||
| + | [[Category: Kiyani, W.]] | ||
| + | [[Category: Kopec, J.]] | ||
| + | [[Category: Newman, J.]] | ||
| + | [[Category: Oberholzer, A.]] | ||
| + | [[Category: Shrestha, L.]] | ||
| + | [[Category: Tallant, C.]] | ||
| + | [[Category: Yue, W W.]] | ||
| + | [[Category: Oxidoreductase]] | ||
Revision as of 11:06, 20 October 2014
Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain
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