2wq4

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[[Image:2wq4.png|left|200px]]
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==N-TERMINAL DOMAIN OF BC2L-C LECTIN FROM BURKHOLDERIA CENOCEPACIA==
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<StructureSection load='2wq4' size='340' side='right' caption='[[2wq4]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2wq4]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_cenocepacia Burkholderia cenocepacia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WQ4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=SFU:METHYL+6-DEOXY-1-SELENO-ALPHA-L-GALACTOPYRANOSIDE'>SFU</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wq4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wq4 RCSB], [http://www.ebi.ac.uk/pdbsum/2wq4 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The opportunistic pathogen Burkholderia cenocepacia expresses several soluble lectins, among them BC2L-C. This lectin exhibits two domains: a C-terminal domain with high sequence similarity to the recently described calcium-dependent mannose-binding lectin BC2L-A, and an N-terminal domain of 156 amino acids without similarity to any known protein. The recombinant N-terminal BC2L-C domain is a new lectin with specificity for fucosylated human histo-blood group epitopes H-type 1, Lewis b, and Lewis Y, as determined by glycan array and isothermal titration calorimetry. Methylselenofucoside was used as ligand to solve the crystal structure of the N-terminal BC2L-C domain. Additional molecular modeling studies rationalized the preference for Lewis epitopes. The structure reveals a trimeric jellyroll arrangement with striking similarity to TNF-like proteins, and to BclA, the spore protein from Bacillus anthracis which may play an important role in bioadhesion of anthrax spores in human lungs.
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{{STRUCTURE_2wq4| PDB=2wq4 | SCENE= }}
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A TNF-like trimeric lectin domain from Burkholderia cenocepacia with specificity for fucosylated human histo-blood group antigens.,Sulak O, Cioci G, Delia M, Lahmann M, Varrot A, Imberty A, Wimmerova M Structure. 2010 Jan 13;18(1):59-72. PMID:20152153<ref>PMID:20152153</ref>
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===N-TERMINAL DOMAIN OF BC2L-C LECTIN FROM BURKHOLDERIA CENOCEPACIA===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_20152153}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2wq4]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_cenocepacia Burkholderia cenocepacia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQ4 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:020152153</ref><references group="xtra"/>
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[[Category: Burkholderia cenocepacia]]
[[Category: Burkholderia cenocepacia]]
[[Category: Cioci, G.]]
[[Category: Cioci, G.]]

Revision as of 11:16, 20 October 2014

N-TERMINAL DOMAIN OF BC2L-C LECTIN FROM BURKHOLDERIA CENOCEPACIA

2wq4, resolution 1.42Å

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