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2wsi

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[[Image:2wsi.png|left|200px]]
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==CRYSTAL STRUCTURE OF YEAST FAD SYNTHETASE (FAD1) IN COMPLEX WITH FAD==
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<StructureSection load='2wsi' size='340' side='right' caption='[[2wsi]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2wsi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WSI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WSI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/FAD_synthetase FAD synthetase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.2 2.7.7.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wsi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wsi RCSB], [http://www.ebi.ac.uk/pdbsum/2wsi PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ws/2wsi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Flavin adenine dinucleotide (FAD) synthetase is an essential enzyme responsible for the synthesis of FAD by adenylation of riboflavin monophosphate (FMN). We have solved the 1.9 A resolution structure of Fad1, the yeast FAD synthetase, in complex with the FAD product in the active site. The structure of Fad1 shows it to be a member of the PP-ATPase superfamily. Important conformational differences in the two motifs involved in binding the phosphate moieties of FAD compared to the Candida glabrata FMNT ortholog suggests that this loop is dynamic and undergoes substantial conformational changes during its catalytic cycle.
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{{STRUCTURE_2wsi| PDB=2wsi | SCENE= }}
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Crystal structure of yeast FAD synthetase (Fad1) in complex with FAD.,Leulliot N, Blondeau K, Keller J, Ulryck N, Quevillon-Cheruel S, van Tilbeurgh H J Mol Biol. 2010 May 21;398(5):641-6. Epub 2010 Mar 30. PMID:20359485<ref>PMID:20359485</ref>
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===CRYSTAL STRUCTURE OF YEAST FAD SYNTHETASE (FAD1) IN COMPLEX WITH FAD===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_20359485}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2wsi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WSI OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:020359485</ref><references group="xtra"/>
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[[Category: FAD synthetase]]
[[Category: FAD synthetase]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]

Revision as of 11:19, 20 October 2014

CRYSTAL STRUCTURE OF YEAST FAD SYNTHETASE (FAD1) IN COMPLEX WITH FAD

2wsi, resolution 1.90Å

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