1thd

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[[Image:1thd.png|left|200px]]
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==COMPLEX ORGANIZATION OF DENGUE VIRUS E PROTEIN AS REVEALED BY 9.5 ANGSTROM CRYO-EM RECONSTRUCTION==
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<StructureSection load='1thd' size='340' side='right' caption='[[1thd]], [[Resolution|resolution]] 9.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1thd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2_puerto_rico/pr159-s1/1969 Dengue virus 2 puerto rico/pr159-s1/1969]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1THD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1THD FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tg8|1tg8]], [[1p58|1p58]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1thd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1thd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1thd RCSB], [http://www.ebi.ac.uk/pdbsum/1thd PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dengue virus, a member of the Flaviviridae family, has a surface composed of 180 copies each of the envelope (E) glycoprotein and the membrane (M) protein. The crystal structure of an N-terminal fragment of E has been determined and compared with a previously described structure. The primary difference between these structures is a 10 degrees rotation about a hinge relating the fusion domain DII to domains DI and DIII. These two rigid body components were used for independent fitting of E into the cryo-electron microscopy maps of both immature and mature dengue viruses. The fitted E structures in these two particles showed a difference of 27 degrees between the two components. Comparison of the E structure in its postfusion state with that in the immature and mature virions shows a rotation approximately around the same hinge. Flexibility of E is apparently a functional requirement for assembly and infection of flaviviruses.
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{{STRUCTURE_1thd| PDB=1thd | SCENE= }}
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Conformational changes of the flavivirus E glycoprotein.,Zhang Y, Zhang W, Ogata S, Clements D, Strauss JH, Baker TS, Kuhn RJ, Rossmann MG Structure. 2004 Sep;12(9):1607-18. PMID:15341726<ref>PMID:15341726</ref>
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===COMPLEX ORGANIZATION OF DENGUE VIRUS E PROTEIN AS REVEALED BY 9.5 ANGSTROM CRYO-EM RECONSTRUCTION===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_15341726}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1thd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1THD OCA].
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</StructureSection>
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[[Category: Dengue virus 2 puerto rico/pr159-s1/1969]]
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==Reference==
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<ref group="xtra">PMID:015341726</ref><ref group="xtra">PMID:014528291</ref><references group="xtra"/>
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[[Category: Viruses]]
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[[Category: Baker, T S.]]
[[Category: Baker, T S.]]
[[Category: Clements, D.]]
[[Category: Clements, D.]]

Revision as of 11:23, 20 October 2014

COMPLEX ORGANIZATION OF DENGUE VIRUS E PROTEIN AS REVEALED BY 9.5 ANGSTROM CRYO-EM RECONSTRUCTION

1thd, resolution 9.50Å

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