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2o1i

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[[Image:2o1i.png|left|200px]]
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==RH(BPY)2CHRYSI complexed to mismatched DNA==
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<StructureSection load='2o1i' size='340' side='right' caption='[[2o1i]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2o1i]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O1I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O1I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=R1C:BIS(2,2-BIPYRIDINE-KAPPA~2~N~1~,N~1~)[CHRYSENE-5,6-DIIMINATO(2-)-KAPPA~2~N,N]RHODIUM(4+)'>R1C</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o1i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o1i RCSB], [http://www.ebi.ac.uk/pdbsum/2o1i PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report the 1.1-A resolution crystal structure of a bulky rhodium complex bound to two different DNA sites, mismatched and matched in the oligonucleotide 5'-(dCGGAAATTCCCG)2-3'. At the AC mismatch site, the structure reveals ligand insertion from the minor groove with ejection of both mismatched bases and elucidates how destabilized mispairs in DNA may be recognized. This unique binding mode contrasts with major groove intercalation, observed at a matched site, where doubling of the base pair rise accommodates stacking of the intercalator. Mass spectral analysis reveals different photocleavage products associated with the two binding modes in the crystal, with only products characteristic of mismatch binding in solution. This structure, illustrating two clearly distinct binding modes for a molecule with DNA, provides a rationale for the interrogation and detection of mismatches.
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{{STRUCTURE_2o1i| PDB=2o1i | SCENE= }}
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Insights into finding a mismatch through the structure of a mispaired DNA bound by a rhodium intercalator.,Pierre VC, Kaiser JT, Barton JK Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):429-34. Epub 2006 Dec 28. PMID:17194756<ref>PMID:17194756</ref>
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===RH(BPY)2CHRYSI complexed to mismatched DNA===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_17194756}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2o1i]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O1I OCA].
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</StructureSection>
[[Category: Barton, J K.]]
[[Category: Barton, J K.]]
[[Category: Kaiser, J T.]]
[[Category: Kaiser, J T.]]

Revision as of 11:24, 20 October 2014

RH(BPY)2CHRYSI complexed to mismatched DNA

2o1i, resolution 1.10Å

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