2kve

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[[Image:2kve.png|left|200px]]
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==C-terminal domain of mesencephalic astrocyte-derived neurotrophic factor (MANF)==
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<StructureSection load='2kve' size='340' side='right' caption='[[2kve]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kve]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KVE FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2kvd|2kvd]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kve OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kve RCSB], [http://www.ebi.ac.uk/pdbsum/2kve PDBsum]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN]] Familial pancreatic carcinoma.
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== Function ==
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[[http://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN]] Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.<ref>PMID:12794311</ref> <ref>PMID:18561914</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects neurons and repairs the Parkinson's disease-like symptoms in a rat 6-hydroxydopamine model. We show a three-dimensional solution structure of human MANF that differs drastically from other neurotrophic factors. Remarkably, the C-terminal domain of MANF (C-MANF) is homologous to the SAP domain of Ku70, a well-known inhibitor of pro-apoptotic Bcl-2-associated X protein (Bax). Cellular studies confirm that MANF and C-MANF protect neurons intracellularly as efficiently as Ku70.
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{{STRUCTURE_2kve| PDB=2kve | SCENE= }}
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Neurotrophic factor MANF has a unique mechanism to rescue apoptotic neurons.,Hellman M, Arumae U, Yu LY, Lindholm P, Peranen J, Saarma M, Permi P J Biol Chem. 2010 Nov 3. PMID:21047780<ref>PMID:21047780</ref>
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===C-terminal domain of mesencephalic astrocyte-derived neurotrophic factor (MANF)===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_21047780}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2kve]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVE OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:021047780</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hellman, M H.]]
[[Category: Hellman, M H.]]

Revision as of 11:26, 20 October 2014

C-terminal domain of mesencephalic astrocyte-derived neurotrophic factor (MANF)

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