2l63

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[[Image:2l63.png|left|200px]]
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==NMR solution structure of GLP-2 in 2,2,2 trifluroethanol==
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<StructureSection load='2l63' size='340' side='right' caption='[[2l63]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2l63]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L63 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L63 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2l64|2l64]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l63 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l63 RCSB], [http://www.ebi.ac.uk/pdbsum/2l63 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glucagon-like peptide-2 (GLP-2) is a therapeutic target used in the treatment of short bowel syndrome. In this paper, we present the three dimensional solution structure of GLP-2 peptide determined using nuclear magnetic resonance (NMR) and molecular modelling. The GLP-2 adopts an alpha-helical conformation similar to that of secretin family of hormones. In order to understand the molecular details governing the ligand binding and receptor activation, macromolecular docking studies were performed between the N-terminal extracellular domain of GLP-2 receptor and the GLP-2 hormone using a data driven docking program.
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{{STRUCTURE_2l63| PDB=2l63 | SCENE= }}
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Conformational and molecular interaction studies of glucagon-like peptide-2 with its N-terminal extracellular receptor domain.,Venneti KC, Hewage CM FEBS Lett. 2011 Jan 21;585(2):346-52. Epub 2010 Dec 15. PMID:21167157<ref>PMID:21167157</ref>
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===NMR solution structure of GLP-2 in 2,2,2 trifluroethanol===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_21167157}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2l63]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L63 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:021167157</ref><references group="xtra"/>
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[[Category: Hewage, C M.]]
[[Category: Hewage, C M.]]
[[Category: Venneti, K C.]]
[[Category: Venneti, K C.]]

Revision as of 11:29, 20 October 2014

NMR solution structure of GLP-2 in 2,2,2 trifluroethanol

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