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4qqd
From Proteopedia
(Difference between revisions)
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| - | ==Crystal Structure of | + | ==Crystal Structure of tandem tudor domains of UHRF1 in complex with a small organic molecule== |
<StructureSection load='4qqd' size='340' side='right' caption='[[4qqd]], [[Resolution|resolution]] 2.28Å' scene=''> | <StructureSection load='4qqd' size='340' side='right' caption='[[4qqd]], [[Resolution|resolution]] 2.28Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4qqd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QQD FirstGlance]. <br> | <table><tr><td colspan='2'>[[4qqd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QQD FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=36X:4-METHYL-2,3,4,5,6,7-HEXAHYDRODICYCLOPENTA[B,E]PYRIDIN-8(1H)-IMINE'>36X</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=36X:4-METHYL-2,3,4,5,6,7-HEXAHYDRODICYCLOPENTA[B,E]PYRIDIN-8(1H)-IMINE'>36X</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qqd RCSB], [http://www.ebi.ac.uk/pdbsum/4qqd PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qqd RCSB], [http://www.ebi.ac.uk/pdbsum/4qqd PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/UHRF1_HUMAN UHRF1_HUMAN]] Note=Defects in UHRF1 may be a cause of cancers. Overexpressed in many different forms of human cancers, including bladder, breast, cervical, colorectal and prostate cancers, as well as pancreatic adenocarcinomas, rhabdomyosarcomas and gliomas. Plays an important role in the correlation of histone modification and gene silencing in cancer progression. Expression is associated with a poor prognosis in patients with various cancers, suggesting that it participates in cancer progression. | [[http://www.uniprot.org/uniprot/UHRF1_HUMAN UHRF1_HUMAN]] Note=Defects in UHRF1 may be a cause of cancers. Overexpressed in many different forms of human cancers, including bladder, breast, cervical, colorectal and prostate cancers, as well as pancreatic adenocarcinomas, rhabdomyosarcomas and gliomas. Plays an important role in the correlation of histone modification and gene silencing in cancer progression. Expression is associated with a poor prognosis in patients with various cancers, suggesting that it participates in cancer progression. | ||
Revision as of 08:56, 22 October 2014
Crystal Structure of tandem tudor domains of UHRF1 in complex with a small organic molecule
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