1jwh
From Proteopedia
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| - | [[Image:1jwh.jpg|left|200px]] | + | [[Image:1jwh.jpg|left|200px]] |
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| - | '''Crystal Structure of Human Protein Kinase CK2 Holoenzyme''' | + | {{Structure |
| + | |PDB= 1jwh |SIZE=350|CAPTION= <scene name='initialview01'>1jwh</scene>, resolution 3.10Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER'>ANP</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of Human Protein Kinase CK2 Holoenzyme''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1JWH is a [ | + | 1JWH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JWH OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme., Niefind K, Guerra B, Ermakowa I, Issinger OG, EMBO J. 2001 Oct 1;20(19):5320-31. PMID:[http:// | + | Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme., Niefind K, Guerra B, Ermakowa I, Issinger OG, EMBO J. 2001 Oct 1;20(19):5320-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11574463 11574463] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
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[[Category: protein kinase ck2]] | [[Category: protein kinase ck2]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:09:27 2008'' |
Revision as of 10:09, 20 March 2008
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| , resolution 3.10Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , and | ||||||
| Activity: | Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Human Protein Kinase CK2 Holoenzyme
Overview
The crystal structure of a fully active form of human protein kinase CK2 (casein kinase 2) consisting of two C-terminally truncated catalytic and two regulatory subunits has been determined at 3.1 A resolution. In the CK2 complex the regulatory subunits form a stable dimer linking the two catalytic subunits, which make no direct contact with one another. Each catalytic subunit interacts with both regulatory chains, predominantly via an extended C-terminal tail of the regulatory subunit. The CK2 structure is consistent with its constitutive activity and with a flexible role of the regulatory subunit as a docking partner for various protein kinases. Furthermore it shows an inter-domain mobility in the catalytic subunit known to be functionally important in protein kinases and detected here for the first time directly within one crystal structure.
About this Structure
1JWH is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme., Niefind K, Guerra B, Ermakowa I, Issinger OG, EMBO J. 2001 Oct 1;20(19):5320-31. PMID:11574463
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