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2x79

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[[Image:2x79.png|left|200px]]
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==INWARD FACING CONFORMATION OF MHP1==
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<StructureSection load='2x79' size='340' side='right' caption='[[2x79]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2x79]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Microbacterium_liquefaciens Microbacterium liquefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X79 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X79 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x79 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x79 RCSB], [http://www.ebi.ac.uk/pdbsum/2x79 PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x7/2x79_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of the sodium-benzylhydantoin transport protein Mhp1 from Microbacterium liquefaciens comprises a five-helix inverted repeat, which is widespread among secondary transporters. Here, we report the crystal structure of an inward-facing conformation of Mhp1 at 3.8 angstroms resolution, complementing its previously described structures in outward-facing and occluded states. From analyses of the three structures and molecular dynamics simulations, we propose a mechanism for the transport cycle in Mhp1. Switching from the outward- to the inward-facing state, to effect the inward release of sodium and benzylhydantoin, is primarily achieved by a rigid body movement of transmembrane helices 3, 4, 8, and 9 relative to the rest of the protein. This forms the basis of an alternating access mechanism applicable to many transporters of this emerging superfamily.
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{{STRUCTURE_2x79| PDB=2x79 | SCENE= }}
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Molecular basis of alternating access membrane transport by the sodium-hydantoin transporter Mhp1.,Shimamura T, Weyand S, Beckstein O, Rutherford NG, Hadden JM, Sharples D, Sansom MS, Iwata S, Henderson PJ, Cameron AD Science. 2010 Apr 23;328(5977):470-3. PMID:20413494<ref>PMID:20413494</ref>
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===INWARD FACING CONFORMATION OF MHP1===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_20413494}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2x79]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Microbacterium_liquefaciens Microbacterium liquefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X79 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:020413494</ref><references group="xtra"/>
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[[Category: Microbacterium liquefaciens]]
[[Category: Microbacterium liquefaciens]]
[[Category: Beckstein, O.]]
[[Category: Beckstein, O.]]

Revision as of 12:48, 22 October 2014

INWARD FACING CONFORMATION OF MHP1

2x79, resolution 3.80Å

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