2xyk

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[[Image:2xyk.png|left|200px]]
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==Group II 2-on-2 Hemoglobin from the Plant Pathogen Agrobacterium tumefaciens==
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<StructureSection load='2xyk' size='340' side='right' caption='[[2xyk]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xyk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XYK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xyk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xyk RCSB], [http://www.ebi.ac.uk/pdbsum/2xyk PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Within the 2/2 hemoglobin sub-family, no group II 2/2Hbs from proteobacteria have been so far studied. Here we present the first structural characterization of a group II 2/2Hb from the soil and phytopathogenic bacterium Agrobacterium tumefaciens (At-2/2HbO). The crystal structure of ferric At-2/2HbO (reported at 2.1A resolution) shows the location of specific/unique heme distal site residues (e.g., His(42)CD1, a residue distinctive of proteobacteria group II 2/2Hbs) that surround a heme-liganded water molecule. A highly intertwined hydrogen-bonded network, involving residues Tyr(26)B10, His(42)CD1, Ser(49)E7, Trp(93)G8, and three distal site water molecules, stabilizes the heme-bound ligand. Such a structural organization suggests a path for diatomic ligand diffusion to/from the heme. Neither a similar distal site structuring effect nor the presence of distal site water molecules has been so far observed in group I and group III 2/2Hbs, thus adding new distinctive information to the complex picture of currently available 2/2Hb structural and functional data.
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{{STRUCTURE_2xyk| PDB=2xyk | SCENE= }}
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Structural characterization of a group II 2/2 hemoglobin from the plant pathogen Agrobacterium tumefaciens.,Pesce A, Nardini M, Labarre M, Richard C, Wittenberg JB, Wittenberg BA, Guertin M, Bolognesi M Biochim Biophys Acta. 2010 Nov 9. PMID:21070893<ref>PMID:21070893</ref>
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===Group II 2-on-2 Hemoglobin from the Plant Pathogen Agrobacterium tumefaciens===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_21070893}}
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==About this Structure==
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[[2xyk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XYK OCA].
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==See Also==
==See Also==
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*[[Hemoglobin|Hemoglobin]]
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*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021070893</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Agrobacterium tumefaciens]]
[[Category: Agrobacterium tumefaciens]]
[[Category: Bolognesi, M.]]
[[Category: Bolognesi, M.]]

Revision as of 12:49, 22 October 2014

Group II 2-on-2 Hemoglobin from the Plant Pathogen Agrobacterium tumefaciens

2xyk, resolution 2.10Å

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