2xvc

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[[Image:2xvc.png|left|200px]]
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==MOLECULAR AND STRUCTURAL BASIS OF ESCRT-III RECRUITMENT TO MEMBRANES DURING ARCHAEAL CELL DIVISION==
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<StructureSection load='2xvc' size='340' side='right' caption='[[2xvc]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xvc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XVC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xvc RCSB], [http://www.ebi.ac.uk/pdbsum/2xvc PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Members of the crenarchaeal kingdom, such as Sulfolobus, divide by binary fission yet lack genes for the otherwise near-ubiquitous tubulin and actin superfamilies of cytoskeletal proteins. Recent work has established that Sulfolobus homologs of the eukaryotic ESCRT-III and Vps4 components of the ESCRT machinery play an important role in Sulfolobus cell division. In eukaryotes, several pathways recruit ESCRT-III proteins to their sites of action. However, the positioning determinants for archaeal ESCRT-III are not known. Here, we identify a protein, CdvA, that is responsible for recruiting Sulfolobus ESCRT-III to membranes. Overexpression of the isolated ESCRT-III domain that interacts with CdvA results in the generation of nucleoid-free cells. Furthermore, CdvA and ESCRT-III synergize to deform archaeal membranes in vitro. The structure of the CdvA/ESCRT-III interface gives insight into the evolution of the more complex and modular eukaryotic ESCRT complex.
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{{STRUCTURE_2xvc| PDB=2xvc | SCENE= }}
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Molecular and Structural Basis of ESCRT-III Recruitment to Membranes during Archaeal Cell Division.,Samson RY, Obita T, Hodgson B, Shaw MK, Chong PL, Williams RL, Bell SD Mol Cell. 2011 Jan 21;41(2):186-96. PMID:21255729<ref>PMID:21255729</ref>
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===MOLECULAR AND STRUCTURAL BASIS OF ESCRT-III RECRUITMENT TO MEMBRANES DURING ARCHAEAL CELL DIVISION===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_21255729}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2xvc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVC OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:021255729</ref><references group="xtra"/>
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[[Category: Sulfolobus solfataricus]]
[[Category: Sulfolobus solfataricus]]
[[Category: Bell, S D.]]
[[Category: Bell, S D.]]

Revision as of 12:57, 22 October 2014

MOLECULAR AND STRUCTURAL BASIS OF ESCRT-III RECRUITMENT TO MEMBRANES DURING ARCHAEAL CELL DIVISION

2xvc, resolution 2.15Å

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