2xq3

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[[Image:2xq3.png|left|200px]]
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==PENTAMERIC LIGAND GATED ION CHANNEL GLIC IN COMPLEX WITH BR-LIDOCAINE==
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<StructureSection load='2xq3' size='340' side='right' caption='[[2xq3]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xq3]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQ3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xqa|2xqa]], [[2xq9|2xq9]], [[2xq7|2xq7]], [[2xq5|2xq5]], [[2xq8|2xq8]], [[2xq4|2xq4]], [[2xq6|2xq6]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xq3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xq3 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The flow of ions through cation-selective members of the pentameric ligand-gated ion channel family is inhibited by a structurally diverse class of molecules that bind to the transmembrane pore in the open state of the protein. To obtain insight into the mechanism of channel block, we have investigated the binding of positively charged inhibitors to the open channel of the bacterial homolog GLIC by using X-ray crystallography and electrophysiology. Our studies reveal the location of two regions for interactions, with larger blockers binding in the center of the membrane and divalent transition metal ions binding to the narrow intracellular pore entry. The results provide a structural foundation for understanding the interactions of the channel with inhibitors that is relevant for the entire family.
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{{STRUCTURE_2xq3| PDB=2xq3 | SCENE= }}
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Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel.,Hilf RJ, Bertozzi C, Zimmermann I, Reiter A, Trauner D, Dutzler R Nat Struct Mol Biol. 2010 Nov;17(11):1330-1336. Epub 2010 Oct 31. PMID:21037567<ref>PMID:21037567</ref>
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===PENTAMERIC LIGAND GATED ION CHANNEL GLIC IN COMPLEX WITH BR-LIDOCAINE===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_21037567}}
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==About this Structure==
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[[2xq3]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ3 OCA].
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==See Also==
==See Also==
*[[Ion channels|Ion channels]]
*[[Ion channels|Ion channels]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021037567</ref><ref group="xtra">PMID:018987630</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Gloeobacter violaceus pcc 7421]]
[[Category: Gloeobacter violaceus pcc 7421]]
[[Category: Bertozzi, C.]]
[[Category: Bertozzi, C.]]

Revision as of 12:57, 22 October 2014

PENTAMERIC LIGAND GATED ION CHANNEL GLIC IN COMPLEX WITH BR-LIDOCAINE

2xq3, resolution 3.50Å

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