2xk5

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[[Image:2xk5.png|left|200px]]
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==CRYSTAL STRUCTURE OF K6-LINKED DIUBIQUITIN==
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<StructureSection load='2xk5' size='340' side='right' caption='[[2xk5]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xk5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XK5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XK5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xqq|1xqq]], [[2jf5|2jf5]], [[1ubq|1ubq]], [[2gbj|2gbj]], [[2gbk|2gbk]], [[1zgu|1zgu]], [[2g45|2g45]], [[2j7q|2j7q]], [[2wdt|2wdt]], [[1f9j|1f9j]], [[2bgf|2bgf]], [[1tbe|1tbe]], [[1fxt|1fxt]], [[2ayo|2ayo]], [[1xd3|1xd3]], [[1gjz|1gjz]], [[1ubi|1ubi]], [[1g6j|1g6j]], [[1nbf|1nbf]], [[1sif|1sif]], [[2xew|2xew]], [[1d3z|1d3z]], [[2w9n|2w9n]], [[1ogw|1ogw]], [[2gbn|2gbn]], [[1yx5|1yx5]], [[2gbm|2gbm]], [[1c3t|1c3t]], [[1q5w|1q5w]], [[1yx6|1yx6]], [[1s1q|1s1q]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xk5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xk5 RCSB], [http://www.ebi.ac.uk/pdbsum/2xk5 PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xk/2xk5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ubiquitination is a reversible post-translational modification that regulates a myriad of eukaryotic functions. Our ability to study the effects of ubiquitination is often limited by the inaccessibility of homogeneously ubiquitinated proteins. In particular, elucidating the roles of the so-called 'atypical' ubiquitin chains (chains other than Lys48- or Lys63-linked ubiquitin), which account for a large fraction of ubiquitin polymers, is challenging because the enzymes for their biosynthesis are unknown. Here we combine genetic code expansion, intein chemistry and chemoselective ligations to synthesize 'atypical' ubiquitin chains. We solve the crystal structure of Lys6-linked diubiquitin, which is distinct from that of structurally characterized ubiquitin chains, providing a molecular basis for the different biological functions this linkage may regulate. Moreover, we profile a panel containing 10% of the known human deubiquitinases on Lys6- and Lys29-linked ubiquitin and discover that TRABID cleaves the Lys29 linkage 40-fold more efficiently than the Lys63 linkage.
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{{STRUCTURE_2xk5| PDB=2xk5 | SCENE= }}
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Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase.,Virdee S, Ye Y, Nguyen DP, Komander D, Chin JW Nat Chem Biol. 2010 Oct;6(10):750-7. Epub 2010 Aug 29. PMID:20802491<ref>PMID:20802491</ref>
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===CRYSTAL STRUCTURE OF K6-LINKED DIUBIQUITIN===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_20802491}}
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==About this Structure==
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[[2xk5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XK5 OCA].
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==See Also==
==See Also==
*[[Ubiquitin|Ubiquitin]]
*[[Ubiquitin|Ubiquitin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020802491</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chin, J W.]]
[[Category: Chin, J W.]]

Revision as of 13:06, 22 October 2014

CRYSTAL STRUCTURE OF K6-LINKED DIUBIQUITIN

2xk5, resolution 3.00Å

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