2xs8

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[[Image:2xs8.png|left|200px]]
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==CRYSTAL STRUCTURE OF ALIX IN COMPLEX WITH THE SIVAGMTAN-1 AYDPARKLL LATE DOMAIN==
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<StructureSection load='2xs8' size='340' side='right' caption='[[2xs8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xs8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XS8 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xs8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xs8 RCSB], [http://www.ebi.ac.uk/pdbsum/2xs8 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Retroviral Gag proteins contain short late domain motifs that recruit cellular ESCRT pathway proteins to facilitate virus budding. ALIX-binding late domains often contain the core consensus sequence: "YPXnL" (where Xn can vary in sequence and length). However, some SIV Gag proteins lack this consensus sequence, yet still bind ALIX. We mapped divergent, ALIX-binding late domains within the p6(Gag) proteins of SIVmac239 (40SREKPYKEVTEDLLHLNSLF59) and SIVagmTan-1 (24AAGAYDPARKLLEQYAKK41). Crystal structures revealed that anchoring tyrosines (bold) and nearby hydrophobic residues (underlined) contact the ALIX V domain, revealing how lentiviruses employ a diverse family of late domain sequences to bind ALIX and promote virus budding.
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{{STRUCTURE_2xs8| PDB=2xs8 | SCENE= }}
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Identification and Structural Characterization of the ALIX-Binding Late Domains of SIVmac239 and SIVagmTan-1.,Zhai Q, Landesman M, Robinson H, Sundquist WI, Hill CP J Virol. 2010 Oct 20. PMID:20962096<ref>PMID:20962096</ref>
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===CRYSTAL STRUCTURE OF ALIX IN COMPLEX WITH THE SIVAGMTAN-1 AYDPARKLL LATE DOMAIN===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_20962096}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2xs8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XS8 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:020962096</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hill, C P.]]
[[Category: Hill, C P.]]

Revision as of 13:21, 22 October 2014

CRYSTAL STRUCTURE OF ALIX IN COMPLEX WITH THE SIVAGMTAN-1 AYDPARKLL LATE DOMAIN

2xs8, resolution 2.50Å

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