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1k09
From Proteopedia
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| - | [[Image:1k09.jpg|left|200px]] | + | [[Image:1k09.jpg|left|200px]] |
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| - | '''Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein''' | + | {{Structure |
| + | |PDB= 1k09 |SIZE=350|CAPTION= <scene name='initialview01'>1k09</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1K09 is a [ | + | 1K09 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K09 OCA]. |
==Reference== | ==Reference== | ||
| - | BetaCore, a designed water soluble four-stranded antiparallel beta-sheet protein., Carulla N, Woodward C, Barany G, Protein Sci. 2002 Jun;11(6):1539-51. PMID:[http:// | + | BetaCore, a designed water soluble four-stranded antiparallel beta-sheet protein., Carulla N, Woodward C, Barany G, Protein Sci. 2002 Jun;11(6):1539-51. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12021452 12021452] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Barany, G.]] | [[Category: Barany, G.]] | ||
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[[Category: four-stranded antiparallel beta-sheet]] | [[Category: four-stranded antiparallel beta-sheet]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:10:50 2008'' |
Revision as of 10:10, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein
Overview
BetaCore is a designed approximately 50-residue protein in which two BPTI-derived core modules, CM I and CM II, are connected by a 22-atom cross-link. At low temperature and pH 3, homo- and heteronuclear NMR data report a dominant folded ('f') conformation with well-dispersed chemical shifts, i, i+1 periodicity, numerous long-range NOEs, and slowed amide hydrogen isotope exchange patterns that is a four-stranded antiparallel beta-sheet with nonsymmetrical and specific association of CM I and CM II. BetaCore 'f' conformations undergo reversible, global, moderately cooperative, non-two-state thermal transitions to an equilibrium ensemble of unfolded 'u' conformations. There is a significant energy barrier between 'f' and 'u' conformations. This is the first designed four-stranded antiparallel beta-sheet that folds in water.
About this Structure
1K09 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
BetaCore, a designed water soluble four-stranded antiparallel beta-sheet protein., Carulla N, Woodward C, Barany G, Protein Sci. 2002 Jun;11(6):1539-51. PMID:12021452
Page seeded by OCA on Thu Mar 20 12:10:50 2008
