4k6l

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{{STRUCTURE_4k6l| PDB=4k6l | SCENE= }}
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==Structure of Typhoid Toxin==
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===Structure of Typhoid Toxin===
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<StructureSection load='4k6l' size='340' side='right' caption='[[4k6l]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
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{{ABSTRACT_PUBMED_23842500}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4k6l]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K6L FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k6l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k6l RCSB], [http://www.ebi.ac.uk/pdbsum/4k6l PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Salmonella enterica serovar Typhi (S. Typhi) differs from most other salmonellae in that it causes a life-threatening systemic infection known as typhoid fever. The molecular bases for its unique clinical presentation are unknown. Here we find that the systemic administration of typhoid toxin, a unique virulence factor of S. Typhi, reproduces many of the acute symptoms of typhoid fever in an animal model. We identify specific carbohydrate moieties on specific surface glycoproteins that serve as receptors for typhoid toxin, which explains its broad cell target specificity. We present the atomic structure of typhoid toxin, which shows an unprecedented A2B5 organization with two covalently linked A subunits non-covalently associated to a pentameric B subunit. The structure provides insight into the toxin's receptor-binding specificity and delivery mechanisms and reveals how the activities of two powerful toxins have been co-opted into a single, unique toxin that can induce many of the symptoms characteristic of typhoid fever. These findings may lead to the development of potentially life-saving therapeutics against typhoid fever.
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==Function==
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Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin.,Song J, Gao X, Galan JE Nature. 2013 Jul 18;499(7458):350-4. doi: 10.1038/nature12377. Epub 2013 Jul 10. PMID:23842500<ref>PMID:23842500</ref>
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[[http://www.uniprot.org/uniprot/CDTB_SALTI CDTB_SALTI]] Produces a CDT (cytolethal distending toxin) activity, which causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arrest, chromatin fragmentation, cell distention and nucleus enlargement.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[4k6l]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhi Salmonella enterica subsp. enterica serovar typhi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6L OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023842500</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Salmonella enterica subsp. enterica serovar typhi]]
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</StructureSection>
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[[Category: Galan,J.]]
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[[Category: Galan, J.]]
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[[Category: Gao,X.]]
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[[Category: Gao, X.]]
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[[Category: Song,J.]]
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[[Category: Song, J.]]
[[Category: Bacterial toxin]]
[[Category: Bacterial toxin]]
[[Category: Complex]]
[[Category: Complex]]
[[Category: Sugar]]
[[Category: Sugar]]
[[Category: Toxin]]
[[Category: Toxin]]

Revision as of 09:15, 29 October 2014

Structure of Typhoid Toxin

4k6l, resolution 2.39Å

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