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4o64

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{{STRUCTURE_4o64| PDB=4o64 | SCENE= }}
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==Zinc fingers of KDM2B==
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===Zinc fingers of KDM2B===
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<StructureSection load='4o64' size='340' side='right' caption='[[4o64]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4o64]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O64 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O64 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/KDM2B_HUMAN KDM2B_HUMAN]] Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<ref>PMID:16362057</ref> <ref>PMID:17994099</ref>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o64 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o64 RCSB], [http://www.ebi.ac.uk/pdbsum/4o64 PDBsum]</span></td></tr>
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==About this Structure==
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</table>
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[[4o64]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O64 OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Arrowsmith, C H.]]
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<references group="xtra"/><references/>
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[[Category: Human]]
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[[Category: Arrowsmith,C H.]]
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[[Category: Bountra, C.]]
[[Category: Bountra, C.]]
[[Category: Edwards, A M.]]
[[Category: Edwards, A M.]]

Revision as of 09:33, 29 October 2014

Zinc fingers of KDM2B

4o64, resolution 2.13Å

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