1k1v
From Proteopedia
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| - | [[Image:1k1v.gif|left|200px]] | + | [[Image:1k1v.gif|left|200px]] |
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| - | '''Solution Structure of the DNA-Binding Domain of MafG''' | + | {{Structure |
| + | |PDB= 1k1v |SIZE=350|CAPTION= <scene name='initialview01'>1k1v</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Solution Structure of the DNA-Binding Domain of MafG''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1K1V is a [ | + | 1K1V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K1V OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of the DNA-binding domain of MafG., Kusunoki H, Motohashi H, Katsuoka F, Morohashi A, Yamamoto M, Tanaka T, Nat Struct Biol. 2002 Apr;9(4):252-6. PMID:[http:// | + | Solution structure of the DNA-binding domain of MafG., Kusunoki H, Motohashi H, Katsuoka F, Morohashi A, Yamamoto M, Tanaka T, Nat Struct Biol. 2002 Apr;9(4):252-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11875518 11875518] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: transcription factor]] | [[Category: transcription factor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:11:22 2008'' |
Revision as of 10:11, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution Structure of the DNA-Binding Domain of MafG
Overview
The Maf family proteins, which constitute a subgroup of basic region-leucine zipper (bZIP) proteins, function as transcriptional regulators of cellular differentiation. Together with the basic region, the Maf extended homology region (EHR), conserved only within the Maf family, defines the DNA binding specific to Mafs. Here we present the first NMR-derived structure of the DNA-binding domain (residues 1-76) of MafG, which contains the EHR and the basic region. The structure consists of three alpha-helices and resembles the fold of the DNA-binding domain of Skn-1, a developmental transcription factor of Caenorhabditis elegans. The structural similarity between MafG and Skn-1 enables us to propose a possible mechanism by which Maf family proteins recognize their consensus DNA sequences.
About this Structure
1K1V is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Solution structure of the DNA-binding domain of MafG., Kusunoki H, Motohashi H, Katsuoka F, Morohashi A, Yamamoto M, Tanaka T, Nat Struct Biol. 2002 Apr;9(4):252-6. PMID:11875518
Page seeded by OCA on Thu Mar 20 12:11:22 2008
