2mf7
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ''' | + | ==Solution structure of the ims domain of the mitochondrial import protein TIM21 from S. cerevisiae== |
| + | <StructureSection load='2mf7' size='340' side='right' caption='[[2mf7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2mf7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MF7 FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ciu|2ciu]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mf7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mf7 RCSB], [http://www.ebi.ac.uk/pdbsum/2mf7 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The presequence translocase TIM23 is a highly dynamic complex in which its subunits can adopt multiple conformations and undergo association-dissociation to facilitate import of proteins into mitochondria. Despite the importance of protein-protein interactions in TIM23, little is known about the molecular details of these processes. Using nuclear magnetic resonance spectroscopy, we characterized the dynamic interaction network of the intermembrane space domains of Tim23, Tim21, Tim50, and Tom22 at single-residue level. We show that Tim23(IMS) contains multiple sites to efficiently interact with the intermembrane space domain of Tim21 and to bind to Tim21, Tim50, and Tom22. In addition, we reveal the atomic details of the dynamic Tim23(IMS)-Tim21(IMS) complex. The combined data support a central role of the intermembrane space domain of Tim23 in the formation and regulation of the presequence translocase. | ||
| - | + | Molecular Basis of the Dynamic Structure of the TIM23 Complex in the Mitochondrial Intermembrane Space.,Bajaj R, Jaremko L, Jaremko M, Becker S, Zweckstetter M Structure. 2014 Oct 7;22(10):1501-11. doi: 10.1016/j.str.2014.07.015. Epub 2014, Sep 25. PMID:25263020<ref>PMID:25263020</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bajaj, R.]] | ||
| + | [[Category: Becker, S.]] | ||
| + | [[Category: Jaremko, L.]] | ||
| + | [[Category: Jaremko, M.]] | ||
| + | [[Category: Zweckstetter, M.]] | ||
| + | [[Category: Ims domain]] | ||
| + | [[Category: Membrane]] | ||
| + | [[Category: Mitochondria]] | ||
| + | [[Category: Mitochondrial import protein]] | ||
| + | [[Category: Protein transport]] | ||
| + | [[Category: Translocation]] | ||
Revision as of 11:19, 29 October 2014
Solution structure of the ims domain of the mitochondrial import protein TIM21 from S. cerevisiae
| |||||||||||
