4whj
From Proteopedia
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| - | ''' | + | ==Myxovirus Resistance Protein 2 (MxB)== |
| + | <StructureSection load='4whj' size='340' side='right' caption='[[4whj]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4whj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WHJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WHJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4whj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4whj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4whj RCSB], [http://www.ebi.ac.uk/pdbsum/4whj PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The myxovirus resistance (Mx) proteins are interferon-induced dynamin GTPases that can inhibit a variety of viruses. Recently, MxB, but not MxA, was shown to restrict HIV-1 by an unknown mechanism that likely occurs in close proximity to the host cell nucleus and involves the viral capsid. Here, we present the crystal structure of MxB and reveal determinants involved in HIV-1 restriction. MxB adopts an extended antiparallel dimer and dimerization, but not higher-ordered oligomerization, is critical for restriction. Although MxB is structurally similar to MxA, the orientation of individual domains differs between MxA and MxB, and their antiviral functions rely on separate determinants, indicating distinct mechanisms for virus inhibition. Additionally, MxB directly binds the HIV-1 capsid, and this interaction depends on dimerization and the N terminus of MxB as well as the assembled capsid lattice. These insights establish a framework for understanding the mechanism by which MxB restricts HIV-1. | ||
| - | + | Structural Insight into HIV-1 Restriction by MxB.,Fribourgh JL, Nguyen HC, Matreyek KA, Alvarez FJ, Summers BJ, Dewdney TG, Aiken C, Zhang P, Engelman A, Xiong Y Cell Host Microbe. 2014 Oct 8. pii: S1931-3128(14)00354-0. doi:, 10.1016/j.chom.2014.09.021. PMID:25312384<ref>PMID:25312384</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fribourgh, J L.]] | ||
| + | [[Category: Nguyen, H C.]] | ||
| + | [[Category: Xiong, Y.]] | ||
| + | [[Category: 4-helix bundle]] | ||
| + | [[Category: Antiviral protein]] | ||
| + | [[Category: Dimer]] | ||
| + | [[Category: Gtpase]] | ||
| + | [[Category: Hydrolase]] | ||
Revision as of 11:21, 29 October 2014
Myxovirus Resistance Protein 2 (MxB)
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