1k40
From Proteopedia
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| - | [[Image:1k40.gif|left|200px]] | + | [[Image:1k40.gif|left|200px]] |
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| - | '''crystal structure of the FAT domain of focal adhesion kinase''' | + | {{Structure |
| + | |PDB= 1k40 |SIZE=350|CAPTION= <scene name='initialview01'>1k40</scene>, resolution 2.25Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''crystal structure of the FAT domain of focal adhesion kinase''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1K40 is a [ | + | 1K40 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K40 OCA]. |
==Reference== | ==Reference== | ||
| - | The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin., Hayashi I, Vuori K, Liddington RC, Nat Struct Biol. 2002 Feb;9(2):101-6. PMID:[http:// | + | The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin., Hayashi I, Vuori K, Liddington RC, Nat Struct Biol. 2002 Feb;9(2):101-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11799401 11799401] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: helix bundle]] | [[Category: helix bundle]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:12:17 2008'' |
Revision as of 10:12, 20 March 2008
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| , resolution 2.25Å | |||||||
|---|---|---|---|---|---|---|---|
| Activity: | Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
crystal structure of the FAT domain of focal adhesion kinase
Overview
Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal 'focal adhesion targeting' (FAT) region is necessary and sufficient for localizing FAK to focal adhesions. We have determined the crystal structure of FAT and show that it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not. We show by mutagenesis that paxillin binding involves two hydrophobic patches on opposite faces of the bundle and propose a model in which two LD motifs of paxillin adopt amphipathic helices that augment the hydrophobic core of FAT, creating a six-helix bundle.
About this Structure
1K40 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin., Hayashi I, Vuori K, Liddington RC, Nat Struct Biol. 2002 Feb;9(2):101-6. PMID:11799401
Page seeded by OCA on Thu Mar 20 12:12:17 2008
