1k4r

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[[Image:1k4r.gif|left|200px]]<br /><applet load="1k4r" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1k4r.gif|left|200px]]
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caption="1k4r, resolution 24.&Aring;" />
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'''Structure of Dengue Virus'''<br />
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{{Structure
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|PDB= 1k4r |SIZE=350|CAPTION= <scene name='initialview01'>1k4r</scene>, resolution 24.&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''Structure of Dengue Virus'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1K4R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus Tick-borne encephalitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4R OCA].
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1K4R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus Tick-borne encephalitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4R OCA].
==Reference==
==Reference==
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Structure of dengue virus: implications for flavivirus organization, maturation, and fusion., Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH, Cell. 2002 Mar 8;108(5):717-25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11893341 11893341]
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Structure of dengue virus: implications for flavivirus organization, maturation, and fusion., Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH, Cell. 2002 Mar 8;108(5):717-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11893341 11893341]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Tick-borne encephalitis virus]]
[[Category: Tick-borne encephalitis virus]]
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[[Category: icosahedral virus]]
[[Category: icosahedral virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:30:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:12:41 2008''

Revision as of 10:12, 20 March 2008

Image:1k4r.gif


PDB ID 1k4r

Drag the structure with the mouse to rotate
, resolution 24.Å
Coordinates: save as pdb, mmCIF, xml



Structure of Dengue Virus


Overview

The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, has a less-ordered structure than the external, icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral asymmetric unit do not have quasiequivalent symmetric environments. Difference maps indicate the location of the small membrane protein M relative to the overlaying scaffold of E dimers. The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane.

About this Structure

1K4R is a Single protein structure of sequence from Tick-borne encephalitis virus. Full crystallographic information is available from OCA.

Reference

Structure of dengue virus: implications for flavivirus organization, maturation, and fusion., Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH, Cell. 2002 Mar 8;108(5):717-25. PMID:11893341

Page seeded by OCA on Thu Mar 20 12:12:41 2008

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