2yja
From Proteopedia
(Difference between revisions)
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| - | [[ | + | ==STAPLED PEPTIDES BINDING TO ESTROGEN RECEPTOR ALPHA.== |
| + | <StructureSection load='2yja' size='340' side='right' caption='[[2yja]], [[Resolution|resolution]] 1.82Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2yja]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YJA FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EST:ESTRADIOL'>EST</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yat|2yat]], [[1xp1|1xp1]], [[1qkt|1qkt]], [[1r5k|1r5k]], [[1zky|1zky]], [[2bj4|2bj4]], [[1akf|1akf]], [[1hcp|1hcp]], [[1hcq|1hcq]], [[1a52|1a52]], [[1qku|1qku]], [[1g50|1g50]], [[1xp6|1xp6]], [[1pcg|1pcg]], [[2b1v|2b1v]], [[2jf9|2jf9]], [[1uom|1uom]], [[1yim|1yim]], [[2ayr|2ayr]], [[3ert|3ert]], [[1yin|1yin]], [[1err|1err]], [[1x7r|1x7r]], [[3erd|3erd]], [[1l2i|1l2i]], [[1xp9|1xp9]], [[2fai|2fai]], [[1gwr|1gwr]], [[1sj0|1sj0]], [[2jfa|2jfa]], [[1gwq|1gwq]], [[1xpc|1xpc]], [[1x7e|1x7e]], [[1xqc|1xqc]], [[1ere|1ere]], [[2yjd|2yjd]], [[2ldd|2ldd]], [[2lda|2lda]], [[2ldc|2ldc]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yja OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yja RCSB], [http://www.ebi.ac.uk/pdbsum/2yja PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Synthetic peptides that specifically bind nuclear hormone receptors offer an alternative approach to small molecules for the modulation of receptor signaling and subsequent gene expression. Here we describe the design of a series of novel stapled peptides that bind the coactivator peptide site of estrogen receptors. Using a number of biophysical techniques, including crystal structure analysis of receptor-stapled peptide complexes, we describe in detail the molecular interactions and demonstrate that all-hydrocarbon staples modulate molecular recognition events. The findings have implications for the design of stapled peptides in general. | ||
| - | + | Design and structure of stapled peptides binding to estrogen receptors.,Phillips C, Roberts LR, Schade M, Bazin R, Bent A, Davies NL, Moore R, Pannifer AD, Pickford AR, Prior SH, Read CM, Scott A, Brown DG, Xu B, Irving SL J Am Chem Soc. 2011 Jun 29;133(25):9696-9. Epub 2011 Jun 6. PMID:21612236<ref>PMID:21612236</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bazin, R.]] | [[Category: Bazin, R.]] | ||
Revision as of 11:54, 29 October 2014
STAPLED PEPTIDES BINDING TO ESTROGEN RECEPTOR ALPHA.
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