328d

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[[Image:328d.png|left|200px]]
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==STRUCTURE OF A D(CGCGAATTCGCG)2-SN7167 COMPLEX==
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<StructureSection load='328d' size='340' side='right' caption='[[328d]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[328d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=328D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=328D FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SN7:4-[4-[2-AMINO-4-[4,6-(N-METHYLQUINOLINIUM)AMINO]BENZAMIDO]ANILINO]-N-METHYLPYRIDINIUM+MESYLATE'>SN7</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=328d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=328d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=328d RCSB], [http://www.ebi.ac.uk/pdbsum/328d PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The X-ray crystal structure of the complex between the synthetic antitumour and antiviral DNA binding ligand SN 7167 and the DNA oligonucleotide d(CGCGAATTCGCG)2 has been determined to an R factor of 18.3% at 2.6 A resolution. The ligand is located within the minor groove and covers almost 6 bp with the 1-methylpyridinium ring extending as far as the C9-G16 base pair and the 1-methylquinolinium ring lying between the G4-C21 and A5-T20 base pairs. The ligand interacts only weakly with the DNA, as evidenced by long range contacts and shallow penetration into the groove. This structure is compared with that of the complex between the parent compound SN 6999 and the alkylated DNA sequence d(CGC[e6G]AATTCGCG)2. There are significant differences between the two structures in the extent of DNA bending, ligand conformation and groove binding.
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{{STRUCTURE_328d| PDB=328d | SCENE= }}
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Minor groove binding of a bis-quaternary ammonium compound: the crystal structure of SN 7167 bound to d(CGCGAATTCGCG)2.,Squire CJ, Clark GR, Denny WA Nucleic Acids Res. 1997 Oct 15;25(20):4072-8. PMID:9321660<ref>PMID:9321660</ref>
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===STRUCTURE OF A D(CGCGAATTCGCG)2-SN7167 COMPLEX===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_9321660}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[328d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=328D OCA].
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</StructureSection>
[[Category: Clark, G R.]]
[[Category: Clark, G R.]]
[[Category: Denny, W A.]]
[[Category: Denny, W A.]]

Revision as of 11:58, 29 October 2014

STRUCTURE OF A D(CGCGAATTCGCG)2-SN7167 COMPLEX

328d, resolution 2.60Å

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