2ypr
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of the DNA binding ETS domain of human protein FEV== | |
| - | + | <StructureSection load='2ypr' size='340' side='right' caption='[[2ypr]], [[Resolution|resolution]] 2.64Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2ypr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YPR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ypr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ypr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ypr RCSB], [http://www.ebi.ac.uk/pdbsum/2ypr PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | == | + | == Disease == |
| - | [[2ypr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPR OCA]. | + | [[http://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN]] Disease susceptibility may be associated with variations affecting the gene represented in this entry. A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity. |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN]] Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.<ref>PMID:12761502</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Allerston, C K.]] | [[Category: Allerston, C K.]] | ||
Revision as of 12:03, 29 October 2014
Crystal structure of the DNA binding ETS domain of human protein FEV
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