2yat
From Proteopedia
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| - | [[ | + | ==Crystal structure of estradiol derived metal chelate and estrogen receptor-ligand binding domain complex== |
| + | <StructureSection load='2yat' size='340' side='right' caption='[[2yat]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2yat]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YAT FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EEU:ESTRADIOL-PYRIDINIUM+TETRAACETIC+ACID'>EEU</scene>, <scene name='pdbligand=EU:EUROPIUM+ION'>EU</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xp1|1xp1]], [[1qkt|1qkt]], [[1r5k|1r5k]], [[1zky|1zky]], [[2bj4|2bj4]], [[1hcp|1hcp]], [[1akf|1akf]], [[1hcq|1hcq]], [[1a52|1a52]], [[1qku|1qku]], [[1xp6|1xp6]], [[1g50|1g50]], [[1pcg|1pcg]], [[2jf9|2jf9]], [[2b1v|2b1v]], [[1uom|1uom]], [[1yim|1yim]], [[2ayr|2ayr]], [[3ert|3ert]], [[1yin|1yin]], [[1err|1err]], [[1x7r|1x7r]], [[3erd|3erd]], [[1l2i|1l2i]], [[2fai|2fai]], [[1xp9|1xp9]], [[2jfa|2jfa]], [[1gwr|1gwr]], [[1sj0|1sj0]], [[1gwq|1gwq]], [[1xpc|1xpc]], [[1x7e|1x7e]], [[1xqc|1xqc]], [[1ere|1ere]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yat OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yat RCSB], [http://www.ebi.ac.uk/pdbsum/2yat PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Selective estrogen receptor modulators, such as estradiol 17alpha-derived metal complexes, have been synthesized as targeted probes for the diagnosis and treatment of breast cancer. Here, we report the detailed 3D structure of estrogen receptor alpha ligand-binding domain (ERalpha-LBD) bound with a novel estradiol-derived metal complex, estradiol-pyridine tetra acetate europium (III) at 2.6A resolution. This structure provides important information pertinent to the design of novel functional ERalpha targeted probes for clinical applications. | ||
| - | + | Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of selective estrogen receptor modulators.,Li MJ, Greenblatt HM, Dym O, Albeck S, Pais A, Gunanathan C, Milstein D, Degani H, Sussman JL J Med Chem. 2011 Apr 7. PMID:21473635<ref>PMID:21473635</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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| - | == | + | |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Albeck, S.]] | [[Category: Albeck, S.]] | ||
Revision as of 12:03, 29 October 2014
Crystal structure of estradiol derived metal chelate and estrogen receptor-ligand binding domain complex
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