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4l2o

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{{STRUCTURE_4l2o| PDB=4l2o | SCENE= }}
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==Crystal structure of human ALDH3A1 with its selective inhibitor 1-(4-fluorophenyl)sulfonyl-2-methylbenzimidazole==
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===Crystal structure of human ALDH3A1 with its selective inhibitor 1-(4-fluorophenyl)sulfonyl-2-methylbenzimidazole===
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<StructureSection load='4l2o' size='340' side='right' caption='[[4l2o]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4l2o]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L2O FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/AL3A1_HUMAN AL3A1_HUMAN]] ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1DD:1-[(4-FLUOROPHENYL)SULFONYL]-2-METHYL-1H-BENZIMIDAZOLE'>1DD</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sza|3sza]], [[3szb|3szb]], [[4l1o|4l1o]]</td></tr>
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==About this Structure==
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase_(NAD(P)(+)) Aldehyde dehydrogenase (NAD(P)(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.5 1.2.1.5] </span></td></tr>
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[[4l2o]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L2O OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l2o RCSB], [http://www.ebi.ac.uk/pdbsum/4l2o PDBsum]</span></td></tr>
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</table>
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__TOC__
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</StructureSection>
[[Category: Hurley, T D.]]
[[Category: Hurley, T D.]]
[[Category: Parajuli, B.]]
[[Category: Parajuli, B.]]
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[[Category: Nadp+ binding]]
[[Category: Nadp+ binding]]
[[Category: Oxidoreductase-inhibitor complex]]
[[Category: Oxidoreductase-inhibitor complex]]
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[[Category: Rossman fold]]
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[[Category: Rossmann fold]]

Revision as of 13:59, 3 November 2014

Crystal structure of human ALDH3A1 with its selective inhibitor 1-(4-fluorophenyl)sulfonyl-2-methylbenzimidazole

4l2o, resolution 1.94Å

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