1k78

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[[Image:1k78.gif|left|200px]]<br /><applet load="1k78" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1k78.gif|left|200px]]
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caption="1k78, resolution 2.25&Aring;" />
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'''Pax5(1-149)+Ets-1(331-440)+DNA'''<br />
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{{Structure
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|PDB= 1k78 |SIZE=350|CAPTION= <scene name='initialview01'>1k78</scene>, resolution 2.25&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= PAX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), ETS-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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}}
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'''Pax5(1-149)+Ets-1(331-440)+DNA'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1K78 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K78 OCA].
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1K78 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K78 OCA].
==Reference==
==Reference==
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Structural studies of Ets-1/Pax5 complex formation on DNA., Garvie CW, Hagman J, Wolberger C, Mol Cell. 2001 Dec;8(6):1267-76. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11779502 11779502]
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Structural studies of Ets-1/Pax5 complex formation on DNA., Garvie CW, Hagman J, Wolberger C, Mol Cell. 2001 Dec;8(6):1267-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11779502 11779502]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: transcription factor]]
[[Category: transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:30:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:13:29 2008''

Revision as of 10:13, 20 March 2008

Image:1k78.gif


PDB ID 1k78

Drag the structure with the mouse to rotate
, resolution 2.25Å
Gene: PAX5 (Homo sapiens), ETS-1 (Mus musculus)
Coordinates: save as pdb, mmCIF, xml



Pax5(1-149)+Ets-1(331-440)+DNA


Contents

Overview

Pax5 regulates the B cell-specific expression of the mb-1 gene together with members of the Ets family of transcriptional activators. The Ets proteins on their own bind poorly to the Pax5/Ets binding site, but can be recruited to the site by cooperative interactions with Pax5. The structure of the ETS domain of Ets-1 and the paired domain of Pax5 bound to DNA reveals the molecular details of the selective recruitment of different Ets proteins by Pax5. Comparison with structures of Ets-1 alone bound to both high- and low-affinity DNA sites reveals that Pax5 alters the Ets-1 contacts with DNA. The ability of one protein to alter the DNA sequence-specific contacts of another provides a general mechanism for combinatorial regulation of transcription.

Disease

Known disease associated with this structure: Lymphoplasmacytoid lymphoma OMIM:[167414]

About this Structure

1K78 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural studies of Ets-1/Pax5 complex formation on DNA., Garvie CW, Hagman J, Wolberger C, Mol Cell. 2001 Dec;8(6):1267-76. PMID:11779502

Page seeded by OCA on Thu Mar 20 12:13:29 2008

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OCA

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